30818-78-1Relevant academic research and scientific papers
Catalyst-Free Regioselective N2 Arylation of 1,2,3-Triazoles Using Diaryl Iodonium Salts
Roshandel, Sahar,Lunn, Maiko J.,Rasul, Golam,Muthiah Ravinson, Daniel Sylvinson,Suri, Suresh C.,Prakash, G. K. Surya
, p. 6255 - 6258 (2019)
The widespread application of 1,2,3-triazoles in pharmaceuticals has resulted in substantial interest toward developing efficient postmodification methods. Whereas there are many postmodification methods available to obtain N1-substituted 1,2,3-triazoles, developing a selective and convenient protocol to synthesize N2-aryl-1,2,3-triazoles has been challenging. We report a catalyst-free and regioselective method to access N2-aryl-1,2,3-triazoles in good to excellent yields (66-97%). This scalable postmodification protocol is effective for a wide range of substrates.
