308240-80-4

Upstream product

• 93454-85-4 (S)-3-(tert-butyldimethylsilyloxy)-2-methylpropionic acid methyl ester 
• 276870-05-4 (3S)-3-hydroxy-4-(triisopropylsilyloxy)butyric acid methyl ester 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 308240-90-6 (+)-(S)-4-tert-Butyldimethylsilyloxy-3-methyl-2-butanone 
• 308240-89-3 (+)-(S)-N-Methoxy-N-methyl-3-tert-butyldimethylsilyloxy-2-methyl-propionamide 
• 308240-79-1 (S)-1-bromo-4-(tert-butyldimethylsilanyloxy)-3-methylbutan-2-one 
• 308240-87-1 (S)-3-(4-Methoxy-benzyloxy)-4-triisopropylsilanyloxy-butyric acid 
• 308240-88-2 (S)-3-(4-Methoxy-benzyloxy)-4-triisopropylsilanyloxy-butyramide 
• 308240-86-0 (S)-3-(4-Methoxy-benzyloxy)-4-triisopropylsilanyloxy-butyric acid methyl ester 
• 308240-78-0 (S)-3-(4-Methoxy-benzyloxy)-4-triisopropylsilanyloxy-thiobutyramide 

Downstream Products

• 308240-95-1 (3R,5S)-5-{2-[(S)-2-(4-Methoxy-benzyloxy)-3-triisopropylsilanyloxy-propyl]-thiazol-4-yl}-3-(2,2,2-trichloro-1,1-dimethyl-ethoxycarbonylamino)-hexanoic acid (E)-(S)-4-iodo-1,3-dimethyl-but-3-enyl ester 
• 308240-82-6 (3R,5S)-5-{2-[(S)-2-(4-Methoxy-benzyloxy)-3-triisopropylsilanyloxy-propyl]-thiazol-4-yl}-3-((R)-toluene-4-sulfinylamino)-hexanoic acid (E)-(S)-4-iodo-1,3-dimethyl-but-3-enyl ester 
• 308240-94-0 (3R,5S)-3-Amino-5-{2-[(S)-2-(4-methoxy-benzyloxy)-3-triisopropylsilanyloxy-propyl]-thiazol-4-yl}-hexanoic acid (E)-(S)-4-iodo-1,3-dimethyl-but-3-enyl ester 
• 308240-92-8 Methanesulfonic acid (R)-2-{2-[(S)-2-(4-methoxy-benzyloxy)-3-triisopropylsilanyloxy-propyl]-thiazol-4-yl}-propyl ester 
• 308240-81-5 (S)-3-{2-[(S)-2-(4-Methoxy-benzyloxy)-3-triisopropylsilanyloxy-propyl]-thiazol-4-yl}-butyronitrile 
• 308240-93-9 (S)-3-{2-[(S)-2-(4-Methoxy-benzyloxy)-3-triisopropylsilanyloxy-propyl]-thiazol-4-yl}-butyraldehyde 
• 139220-18-1 (-)-pateamine 
• 308240-91-7 (R)-2-{2-[(S)-2-(4-Methoxy-benzyloxy)-3-triisopropylsilanyloxy-propyl]-thiazol-4-yl}-propan-1-ol 

Relevant academic research and scientific papers

Total synthesis of (-)-pateamine, a novel polyene bis-macrolide with immunosuppressive activity from the sponge Mycale sp.

A concise and convergent synthesis of the polyene thiazole-containing 19-membered bis-lactone (-)-pateamine 1 is described. The synthesis features both the intra- and intermolecular Stille sp2-sp2 coupling reactions to elaborate the E,Z-diene macrolide core and the side-chain all-E polyene portion of the natural product, and highlights the scope for enantiopure sulfinimine intermediates in the synthesis of chiral β-amino ester moieties in complex structures. (C) 2000 Elsevier Science Ltd.