308242-23-1

Basic information

• Product Name: (3S)-(7-BroMo-2-oxo-5-pyridin-2-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-propionic acid Methyl ester
• Synonyms: (3S)-(7-BroMo-2-oxo-5-pyridin-2-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-propionic acid Methyl ester;Methyl 3-[(3S)-7-bromo-2-oxo-5-(2-pyridinyl)-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]propanoate
• CAS NO: 308242-23-1
• Molecular Formula: C₁₈H₁₆BrN₃O₃
• Molecular Weight: 402.24194
• EINECS: -0
• Mol File: 308242-23-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 545.3±50.0 °C(Predicted)
• Appearance: /
• Density: 1.52±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.15±0.70(Predicted)
• CAS DataBase Reference: (3S)-(7-BroMo-2-oxo-5-pyridin-2-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-propionic acid Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (3S)-(7-BroMo-2-oxo-5-pyridin-2-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-propionic acid Methyl ester(308242-23-1)
• EPA Substance Registry System: (3S)-(7-BroMo-2-oxo-5-pyridin-2-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-propionic acid Methyl ester(308242-23-1)

Safety Data

• Hazardous Substances Data: 308242-23-1(Hazardous Substances Data)

Usage

General Description

The chemical compound "(3S)-(7-BroMo-2-oxo-5-pyridin-2-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-propionic acid Methyl ester" is a methyl ester derivative of a benzodiazepine compound. It contains a bromo and a pyridin-2-yl group, and has a propionic acid side chain. (3S)-(7-BroMo-2-oxo-5-pyridin-2-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-propionic acid Methyl ester likely has pharmacological properties similar to other benzodiazepine derivatives, which are known to have sedative, hypnotic and anxiolytic effects. The presence of the pyridin-2-yl group may also impart specific biological activity to the compound. Further research is needed to fully understand the potential uses and effects of this compound.

Upstream product

• 308243-40-5 4-chlorocarbonyl-4-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid methyl ester 
• 1481642-14-1 (S)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-methoxy-5-oxopentanoic acid 
• 4652-65-7 (S)-2-Benzyloxycarbonylamino-pentanedioic acid 5-methyl ester 
• 1499-55-4 L-glutamic acid 5-methyl ester 
• 45214-91-3 (2S)-2-[(tert-butoxy)carbonylamino]-4-(methoxycarbonyl)butanoic acid 
• 1275616-58-4 C₁₈H₁₈BrN₃O₄*ClH 
• 1275616-57-3 C₂₃H₂₆BrN₃O₆ 
• 1563-56-0 2-amino-5-bromobenzoyl pyridine 
• 109-04-6 2-bromo-pyridine 
• 5794-88-7 5-Bromo-2-aminobenzoic acid 

Downstream Products

• 308242-62-8 Remimazolam 
• 1001415-66-2 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiazepin-4-yl]propionic acid methyl ester benzenesulfonate 

Relevant articles and documents

METHOD FOR PREPARING 3-[(4S)-8-BROMO-1-METHYL-6-(PYRIDIN-2-YL)-4H-IMIDAZO[1,2-A][1,4]BENZODIAZEPIN-4-YL]-PROPIONIC ACID METHYL ESTER, AND COMPOUNDS USEFUL IN SAID METHOD

The present invention relates to a method for preparing 3- [ ( 4S ) -8-bromo-l-methyl-6- (pyridin-2-yl ) -4H-imidazo [1,2- a] [ 1, 4 ] benzodiazepin-4-yl ] -propionic acid methyl ester starting from 3- [ (3S) -7-bromo-2-oxo-5- (pyridin-2-yl ) -2, 3-dihydr

SHORT-ACTING BENZODIAZEPINE DERIVATIVES, PREPARATION METHOD THEREFOR, AND USE THEREOF

The present invention relates to a benzodiazepine derivative of Formula I as a short-acting anesthetic, a pharmaceutical composition comprising the same, a kit comprising the same, a preparation method thereof, an method of anesthesia using the same and use thereof in the manufacture of an anesthetic medicament.

PROCESS FOR PREPARING 3-[(4S)-8-BROMO-1-METHYL-6-(2-PYRIDINYL)-4H-IMIDAZOL[1,2-A][1,4]BENZODIAZEPINE-4-YL]PROPIONIC ACID METHYL ESTER OR THE BENZENE SULFONATE SALT THEREOF, AND COMPOUNDS USEFUL IN THAT PROCESS

The invention concerns a new process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiazepine-4-yl]-propionic acid methyl ester 3-[(4S)-8-bromo-1 -methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiazepine-4-yl]propioni