308242-63-9Relevant articles and documents
Relating the structure, activity, and physical properties of ultrashort-acting benzodiazepine receptor agonists
Pacofsky, Gregory J.,Stafford, Jeffrey A.,Cox, Richard F.,Cowan, Jill R.,Dorsey Jr., George F.,Gonzales, Stephen S.,Kaldor, Istvan,Koszalka, George W.,Lovell, George G.,McIntyre, Maggie S.,Tidwell, Jeffrey H.,Todd, Dan,Whitesell, Graham,Wiard, Robert P.,Feldman, Paul L.
, p. 3219 - 3222 (2007/10/03)
The ultrashort-acting benzodiazepine (USA BZD) agonists reported previously have been structurally modified to improve aqueous solubility. Lactam-to-amidine modifications, replacement of the C5-haloaryl ring, and annulation of heterocycles are presented. These analogues retain BZD receptor potency and full agonism profiles.