308246-22-2

Upstream product

• 308245-94-5 (R)-N-[1'-(2-Furyl)-3'-phenylpropyl]-N-[2-(p-tolylsulfonyloxy)ethyl]toluene-p-sulfonamide 
• 308246-04-0 (R)-N-[1'-(2-Furyl)-3'-phenylpropyl]-N-(2-phenylselenoethyl)toluene-p-sulfonamide 
• 308245-83-2 (R)-N-[1'-(2-Furyl)-3'-phenyloropyl]-2-aminoethanol 
• 182161-99-5 (5S,1'S)-N-[1'-(2-Furyl)-3'-phenylpropyl]-5-phenylmorpholin-2-one 
• 104-53-0 3-phenyl-propionaldehyde 
• 308246-12-0 (R)-N-[1'-(2-Furyl)-3'-phenylpropyl]toluene-p-sulfonamide 

Relevant academic research and scientific papers

Chirally templated boronic acid Mannich reaction in the synthesis of optically active α-amino acids

Adducts from diastereoselective Mannich-type reactions of aldehydes, 2-furylboronic acid and the chiral amine template (S)-5-phenylmorpholin-2-one, were used in the synthesis of a series of enantiomerically pure D-α-amino acids. The direction of diastereocontrol was proved by X-ray crystallography analysis of the reaction products. Results indicated that sequential degradation of diastereomically pure N-furfurylmorpholinones obtained by boronic Mannich condensation, could be carried out to produce amino acids of high optical purity.