30825-14-0Relevant academic research and scientific papers
Synthesis and characterization of hydroxylated mesocarb metabolites for doping control
Vahermo, Mikko,Suominen, Tina,Leinonen, Antti,Yli-Kauhaluoma, Jari
experimental part, p. 201 - 209 (2009/05/09)
The synthesis and method of analysis of hydroxylated mesocarb metabolites are described. Six potential hydroxylated mesocarb metabolites were prepared, characterized, and compared with the mesocarb metabolites synthesized enzymatically in vitro using human liver proteins and also compared with metabolites extracted from human urine after oral administration of mesocarb. p-Hydroxymesocarb was the most prevalent metabolite (conjugated and non-conjugated) observed. With respect to doping analysis, synthesis of p-hydroxymesocarb, the main urinary metabolite of mesocarb, and its availability as a reference material is important.
