308266-48-0

Basic information

• Product Name: 3-[1-(N,N-dibenzylamino)cyclopropyl]propionic acid
• Synonyms: 3-[1-(N,N-dibenzylamino)cyclopropyl]propionic acid
• CAS NO: 308266-48-0
• Molecular Weight: 309.408
• Mol File: 308266-48-0.mol

Chemical Properties

• CAS DataBase Reference: 3-[1-(N,N-dibenzylamino)cyclopropyl]propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[1-(N,N-dibenzylamino)cyclopropyl]propionic acid(308266-48-0)
• EPA Substance Registry System: 3-[1-(N,N-dibenzylamino)cyclopropyl]propionic acid(308266-48-0)

Safety Data

• Hazardous Substances Data: 308266-48-0(Hazardous Substances Data)

Upstream product

• 65790-23-0 4-oxopentanoic acid N,N-dibenzylamide 
• 308266-46-8 N,N-dibenzyl-1-[2-(2-methyl-1,3-dioxolan-2-yl)ethyl]cyclopropan-1-amine 
• 65790-26-3 N,N-dibenzyl-3-(2-methyl[1,3]dioxolan-2-yl)propionamide 
• 308266-47-9 4-[1-(N,N-dibenzylamino)cyclopropyl]butan-2-one 

Downstream Products

• 308266-50-4 3-(1-dibenzylamino-cyclopropyl)-propionic acid methyl ester 
• 308266-51-5 4-azaspiro[2.4]heptan-5-one 

Relevant articles and documents

STAT DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Cyclopropyl building blocks for organic synthesis, 58(+): A new short access to amino acids incorporating an aminocyclopropyl moiety from N,N-dibenzylcarboxamides

Our recently reported titanium-mediated transformation of N,N-dialkylcarboxamides to cyclopropylamines has been applied to N,N-dibenzyl-2-benzyloxyacetamide using a variety of alkylmagnesium bromides to yield 1-(benzyloxymethyl)-1-(dibenzylamino)cyclopropane (15a, 48percent) and 2-substituted analogs 15b-f (33-48percent). These have been transformed in just a few steps into N-Boc-protected methyl esters of 1-aminocyclopropanecarboxylic acid (1, 29percent overall), coronamic acid (2, 35percent) and norcoronamic acid (21percent), 2,3-methanoglutamic acid (21g, 19percent) and 2,3-methanoornithine (211, 12percent). Similarly, the corresponding derivatives of 3,4-methano-γ-aminobutyric acid (26, 23percent) and 4-spirocyclopropane-γ-butyrolactam (32, 44percent) have been synthesized.