308273-67-8

Usage

InChI:InChI=1/C17H21NO2/c1-13(15-7-5-4-6-8-15)18-12-14-9-10-16(19-2)17(11-14)20-3/h4-11,13,18H,12H2,1-3H3/p+1/t13-/m0/s1

Upstream product

• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 120-14-9 3,4-dimethoxy-benzaldehyde 

Downstream Products

• 134430-99-2 methyl (3R,αR)-3-(N-3,4-dimethoxybenzyl-N-α-methylbenzylamino)butanoate 
• 134431-01-9 tert-butyl (3R,αR)-3-(N-3,4-dimethoxybenzyl-N-α-methylbenzylamino)butanoate 
• 134431-00-8 benzyl (3R,αR)-3-(N-3,4-dimethoxybenzyl-N-α-methylbenzylamino)butanoate 
• 1138337-24-2 tert-butyl (1R,2S,6R)-2-[N-benzyl-N-((1S)-α-phenylethyl)amino]-6-ethyl-cyclohexane-carboxylate 
• 1138337-16-2 tert-butyl (1S,2R,6S)-6-[N-(3,4-dimethoxybenzyl)-N-((1R)-α-phenylethyl)-amino]-2-ethyl-cyclohexane-carboxylate 

Relevant academic research and scientific papers

Iron triflate catalyzed reductive amination of aldehydes using sodium borohydride

An efficient and convenient procedure for the reductive amination of aldehydes using NaBH4 in the presence of catalytic amount of Fe(OTf)3 is described.

Production method of (R) -3 hydroxy-3- (2-phenylethyl) hexanoic acid and intermediate thereof

The present invention relates to a production method of (R)-3-hydroxy-3-(2-phenylethyl)hexanoic acid which comprises optical resolution of racemic 3-hydroxy-3-(2-phenylethyl)hexanoic acid with an optically active amine of the formula (VIII) 1wherein R2 is 3,4-dimethoxyphenyl or 2-chlorophenyl. According to the present invention, (R)-3-hydroxy-3-(2-phenylethyl)hexanoic acid useful as a starting material of a pharmaceutical agent can be efficiently produced with a high optical purity and a relatively high total yield.