308281-45-0Relevant academic research and scientific papers
A comparison of electron transfer reagents in the reductive opening of epoxides: Reasons for the superiority of titanocene based complexes
Gans?uer, Andreas,Rinker, Bj?rn
, p. 7017 - 7026 (2002)
Several commonly used electron transfer reagents were compared in their reactivity towards three epoxides. These substrates were designed to allow for a distinction between competing courses of the reaction. It was found that titanocene reagents were clearly superior due to their low Lewis acidity, high reduction tendency towards epoxides, and low reduction tendency towards the pivotal β-metal oxy radical intermediates.
Titanocene catalysed 5-exo cyclisations of unsaturated epoxides- reagent control in radical chemistry
Gansaeuer,Pierobon,Bluhm
, p. 2500 - 2520 (2007/10/03)
A synthetic route to carbocyclic and heterocyclic [3.3.0], [4.3.0] and [5.3.0] systems containing pyrrolidine and tetrahydrofuran units and various other tetrahydrofuran derivatives is presented. The products are of relevance for natural product synthesis and for the synthesis of biologically active compounds. The titanocene catalysed reactions utilises readily available unsaturated epoxides as substrates. A model explaining the diastereoselectivity of cyclisation is presented that should allow for rational design of more selective catalysts.
