308368-55-0

Basic information

• Product Name: 3-(p-chlorophenyl)-2-(3,4-dihydro-2H-5-pyranyl)-1,1,1-trifluoro-2-propanol
• Synonyms: 3-(p-chlorophenyl)-2-(3,4-dihydro-2H-5-pyranyl)-1,1,1-trifluoro-2-propanol
• CAS NO: 308368-55-0
• Molecular Weight: 306.712
• Mol File: 308368-55-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(p-chlorophenyl)-2-(3,4-dihydro-2H-5-pyranyl)-1,1,1-trifluoro-2-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(p-chlorophenyl)-2-(3,4-dihydro-2H-5-pyranyl)-1,1,1-trifluoro-2-propanol(308368-55-0)
• EPA Substance Registry System: 3-(p-chlorophenyl)-2-(3,4-dihydro-2H-5-pyranyl)-1,1,1-trifluoro-2-propanol(308368-55-0)

Safety Data

• Hazardous Substances Data: 308368-55-0(Hazardous Substances Data)

Upstream product

• 109317-74-0 1-(3,4-dihydro-2H-5-pyranyl)-2,2,2-trifluoro-1-ethanone 
• 622-95-7 4-chlorobenzyl bromide 
• 107323-82-0 4-chlorobenzylmagnesium bromide 

Relevant articles and documents

A synthesis of trifluoromethyl-substituted naphthalenes

Alkyl and aryl Grignard reagents add to 1-(3,4-dihydro-2H-5-pyranyl)-2,2,2-trifluoro-1-ethanone by 1,4-addition, but benzyl Grignard reagents react in good yield by 1,2-addition. Dehydration of the resulting alcohols affords intermediate dienes, which readily undergo cyclisation to give substituted trifluoromethyl-naphthalenes. Addition to other trifluoromethylketones permits access to a range of novel fluorinated naphthalenes and benzenes. (C) 2000 Published by Elsevier Science Ltd.