308368-58-3Relevant academic research and scientific papers
A synthesis of trifluoromethyl-substituted naphthalenes
Mellor,El-Sagheer,Salem
, p. 7383 - 7386 (2007/10/03)
Alkyl and aryl Grignard reagents add to 1-(3,4-dihydro-2H-5-pyranyl)-2,2,2-trifluoro-1-ethanone by 1,4-addition, but benzyl Grignard reagents react in good yield by 1,2-addition. Dehydration of the resulting alcohols affords intermediate dienes, which readily undergo cyclisation to give substituted trifluoromethyl-naphthalenes. Addition to other trifluoromethylketones permits access to a range of novel fluorinated naphthalenes and benzenes. (C) 2000 Published by Elsevier Science Ltd.
Synthesis of trifluoromethylnaphthalenes
Mellor, John M,El-Sagheer, Afaf H,El-Tamany, El-Sayed H,Metwally, Reda N
, p. 10067 - 10074 (2007/10/03)
Reaction of 1-(3,4-dihydro-2H-5-pyranyl)-2,2,2-trifluoro-1-ethanone with benzylic Grignard reagents affords by 1,2-addition unsaturated allylic alcohols. These alcohols readily undergo dehydration and cyclisation to give trifluoromethylnaphthalenes. The generality of this procedure was established by reaction with diverse benzyl and allyl Grignard reagents and by reaction of a number of unsaturated ketones. The resulting trifluoromethylnaphthalenes were oxidised to give substituted acetic- and propionic acids. (C) 2000 Elsevier Science Ltd.
