30839-21-5Relevant academic research and scientific papers
Copper(II)-promoted C-C bond formation by oxidative coupling of two C(sp3)-H bonds adjacent to carbonyl group to construct 1,4-diketones and tetrasubstituted furans
Mao, Shuai,Gao, Ya-Ru,Zhang, Shao-Liang,Guo, Dong-Dong,Wang, Yong-Qiang
, p. 876 - 885 (2015/01/30)
The copper(II)-promoted C-C bond formation from the coupling of two C(sp3)-H bonds that are adjacent to a carbonyl group was achieved. This protocol offers a simple and efficient approach to 2,3-disubstituted 1,4-diketones and tetrasubstituted furans. This method features a wide substrate scope and high functional group tolerance.
Silver-Catalyzed Coupling of Two Csp3-H Groups and One-Pot Synthesis of Tetrasubstituted Furans, Thiophenes, and Pyrroles
Mao, Shuai,Zhu, Xue-Qing,Gao, Ya-Ru,Guo, Dong-Dong,Wang, Yong-Qiang
supporting information, p. 11335 - 11339 (2015/08/03)
Silver-catalyzed coupling of two Csp3-H groups to form 1,4-diketones have been developed for the first time. The resultant ketones then undergo cyclization to synthesize tetrasubstituted furans, thiophenes, and pyrroles from benzyl ketone derivatives in a one-pot reaction process. This highly-efficient synthetic method, which utilizes air as the terminal oxidant and readily accessible starting materials, displays a wide substrate scope and broad functional-group tolerance.
Oxidation of Aromatic Compounds. VI. Oxidation of Unsymmetrical Diarylacetylenes in the CF3COOH-CH2Cl2-PbO2 System
Vasil'ev,Rudenko
, p. 1555 - 1584 (2007/10/03)
Oxidation of unsymmetrical diarylacetylenes ArC≡CAr′ in the CF3COOH-CH2Cl2-PbO2 system at 0-2°C in 1-3 h yields either pure 1,2,3,4-tetraaryl-2-butene-1,4-diones or mixtures of three isomeric γ-di-ketones Ar(Ar′CO)C=C(COAr′)Ar, Ar′(ArCO)C=C(COAr)Ar′, and Ar′(ArCO)C=C(COAr′)Ar which are predominantly Z isomers. The effect of electronic properties of the substituents in diarylacetylenes on the regio- and stereoselectivity of the reaction is discussed.
