30839-22-6

Upstream product

• 19172-47-5 Lawessons reagent 
• 30856-48-5 2,3-diphenyl-1,4-di-p-tolylbutane-1,4-dione 
• 3287-02-3 4-(phenylethynyl)toluene 
• 2001-28-7 2-phenyl-1-p-tolyl-ethanone 
• 1889-71-0 4'-chloro-2-phenylacetophenone 

Relevant academic research and scientific papers

Copper(II)-promoted C-C bond formation by oxidative coupling of two C(sp3)-H bonds adjacent to carbonyl group to construct 1,4-diketones and tetrasubstituted furans

The copper(II)-promoted C-C bond formation from the coupling of two C(sp3)-H bonds that are adjacent to a carbonyl group was achieved. This protocol offers a simple and efficient approach to 2,3-disubstituted 1,4-diketones and tetrasubstituted furans. This method features a wide substrate scope and high functional group tolerance.

Silver-Catalyzed Coupling of Two Csp3-H Groups and One-Pot Synthesis of Tetrasubstituted Furans, Thiophenes, and Pyrroles

Silver-catalyzed coupling of two Csp3-H groups to form 1,4-diketones have been developed for the first time. The resultant ketones then undergo cyclization to synthesize tetrasubstituted furans, thiophenes, and pyrroles from benzyl ketone derivatives in a one-pot reaction process. This highly-efficient synthetic method, which utilizes air as the terminal oxidant and readily accessible starting materials, displays a wide substrate scope and broad functional-group tolerance.

Oxidation of Aromatic Compounds. VI. Oxidation of Unsymmetrical Diarylacetylenes in the CF3COOH-CH2Cl2-PbO2 System

Oxidation of unsymmetrical diarylacetylenes ArC≡CAr′ in the CF3COOH-CH2Cl2-PbO2 system at 0-2°C in 1-3 h yields either pure 1,2,3,4-tetraaryl-2-butene-1,4-diones or mixtures of three isomeric γ-di-ketones Ar(Ar′CO)C=C(COAr′)Ar, Ar′(ArCO)C=C(COAr)Ar′, and Ar′(ArCO)C=C(COAr′)Ar which are predominantly Z isomers. The effect of electronic properties of the substituents in diarylacetylenes on the regio- and stereoselectivity of the reaction is discussed.

Reaction of 2,4-Bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulphide with Substituted Butane-1,4-diones: Part II - Novel Synthesis of Substituted Thiophenes and Furans

The reaction of substituted butane-1,4-diones (2) with 2,4-bis(4-methoxyphenyl)1,3,2,4-dithiadiphosphetane-2,4-disulphides (1; Lawesson reagent) has been investigated.While the reaction of 1,2-diacylethane (2k) with 1 leads exclusively to the formation of the corresponding 2,5-disubstituted thiophene (4k) in excellent yield, the interaction of tri- and tetrasubstituted butane-1,4-diones (2a-j) with 1 under identical conditions invariably results in the formation of a mixture of the corresponding thiophenes (4) and furans (3) in varying proportions.The identity of 3 and 4 and also their molar percentages in the product mixtures have been established by GLC and PMR spectral analyses.