3085-79-8

Usage

Uses

Used in Organic Synthesis:
METHYLTRIBUTYLAMMONIUM IODIDE is used as a phase transfer catalyst for facilitating the transfer of iodide ions between immiscible phases, which is crucial in various organic synthesis reactions.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, METHYLTRIBUTYLAMMONIUM IODIDE is utilized as a catalyst to enhance the efficiency of chemical reactions involved in the production of pharmaceutical compounds.
Used in Materials Science:
METHYLTRIBUTYLAMMONIUM IODIDE is employed in materials science for its ability to catalyze reactions that lead to the development of new materials with specific properties.
Used in Chemical Processing:
In chemical processing, METHYLTRIBUTYLAMMONIUM IODIDE is used as a phase transfer catalyst to improve the efficiency of reactions, particularly those involving the transfer of ions between different phases.
It is important to handle METHYLTRIBUTYLAMMONIUM IODIDE with care due to its potential harmful effects if ingested, inhaled, or comes into contact with the skin.

InChI:InChI=1/C13H30N.ClH/c1-5-8-11-14(4,12-9-6-2)13-10-7-3;/h5-13H2,1-4H3;1H/q+1;/p-1

Upstream product

• 102-82-9 tributyl-amine 
• 74-88-4 methyl iodide 

Downstream Products

• 106-98-9 1-butylene 
• 102-82-9 tributyl-amine 
• 34557-54-5 methane 
• 3405-45-6 N-methyldibutylamine 

Relevant academic research and scientific papers

Quaternary ammonium ions can externally block voltage-gated K+ channels. Establishing a theoretical and experimental model that predicts KDS and the selectivity of K+ over Na+ ions

The physicochemical basis for the high ion selectivity of potassium channels is poorly understood. In the present studies, external blockade of cloned voltage-gated potassium channels with alkyl quaternary ammonium ions are analyzed from a model derived from theory and experimental data. Atomic mass units, electrostatic potential residing on the nitrogen atom, the COSMO van der Waals solvent accessible surface, the Onsager solvation model, and the isodensity PCM solvation model are computed at the semi-empirical and the ab initio levels of theory. A structure-activity relationship (SAR) exists between the calculated values and the experimentally obtained KD (mM). The SAR model gives us KD predictions and when K+ and Na+ are incorporated into the model, it dramatically predicts the selectivity of K+ over Na+ ions.

SIGNIFICANCE TEST OF REFRACTIVE INDEX OF SOLVENT IN EVALUATION OF EFFECT OF MEDIUM ON RATES OF QUATERNIZATION REACTIONS OF METHYL IODIDE WITH AMINES

The rate constants have been measured of the reactions of methyl iodide with triethylamine (I) and tributylamine (III) at 293 K in twelve aprotic solvents, methyl iodide with tripropylamine (II) at 293, 313, 323, and 333 K in fifteen solvents differing greatly in their dipole moments, relative permittivities, and refractive indexes, and diiodomethane with tripropylamine in diiodomethane at 293 K (k1 = 2.1 * 10-5 s-1).The aprotic solvents predominantly affect the activation entropy which for the reaction of II varies from -200 J mol-1 s-1 (in cyclohexane) to-108 J mol-1 s-1 (in diiodomethane).The activation enthalpy of the reaction of methyl iodide with tripropylamine (II) is only little affected by aprotic solvents, a significant increase in activation enthalpy has been observed in the case of amphiprotic solvents.The evaluation of effect of medium on the rate constants of the above-mentioned reactions by means of the Kirkwood functions of relative permittivity and refractive index has shown a significant contribution of the refractive index of solvent which is comparable with the effect of relative permittivity.