3086-06-4Relevant articles and documents
4-amino-fluorobenzamides and their use as cytotoxic prodrugs
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, (2008/06/13)
The invention provides a compound which is a 3-fluorobenzamide of the formula (A) STR1 wherein R-NH is the residue of an α-amino acid R-NH2 or oligopeptide R-NH2, and M is a nitrogen mustard group of the formula STR2 wherein Y and L, which may be the same or different in a molecule, are leaving groups; or a pharmaceutically acceptable salt thereof. The compounds are useful as prodrugs for treating cancer.
Novel Prodrugs Which Are Activated to Cytotoxic Alkylating Agents by Carboxypeptidase G2
Springer, Caroline J.,Antoniw, Pari,Bagshawe, Kenneth D.,Searle, Frances,Bisset, Graham M. F.,Jarman, Michael
, p. 677 - 681 (2007/10/02)
The synthesis of three novel prodrugs, 4-amino>benzoyl-L-glutamic acid (7), 4-amino>benzoyl-L-glutamic acid (8), and 4-benzoyl-L-glutamic acid (9), for use as anticancer ag