3086-06-4

Usage

InChI:InChI=1/C16H20Cl2N2O5/c17-7-9-20(10-8-18)12-3-1-11(2-4-12)15(23)19-13(16(24)25)5-6-14(21)22/h1-4,13H,5-10H2,(H,19,23)(H,21,22)(H,24,25)/t13-/m0/s1

Upstream product

• 123724-57-2 di-tert-butyl 4-benzoyl-L-glutamate 
• 76282-66-1 di-tert-butyl (S)-N-(p-aminobenzoyl)-glutamate 
• 32677-01-3 L-glutamic acid di-tert-butyl ester hydrochloride 
• 123724-54-9 di-tert-butyl 4-benzoyl-L-glutamate 

Downstream Products

• 1141-37-3 4-{bis(2-chloroethyl)amino}benzoic acid 
• 56-86-0 L-glutamic acid 

Relevant academic research and scientific papers

4-amino-fluorobenzamides and their use as cytotoxic prodrugs

The invention provides a compound which is a 3-fluorobenzamide of the formula (A) STR1 wherein R-NH is the residue of an α-amino acid R-NH2 or oligopeptide R-NH2, and M is a nitrogen mustard group of the formula STR2 wherein Y and L, which may be the same or different in a molecule, are leaving groups; or a pharmaceutically acceptable salt thereof. The compounds are useful as prodrugs for treating cancer.

Improvements relating to the production of prodrugs

The invention provides compounds of the formula XX: M-Ar-CONH-R, where Ar represents an aromatic ring system, R-NH is the residue of an α-amino acid R-NH2 or oligopeptide R-NH2 and contains at least one carboxylic acid group in the f

Novel Prodrugs Which Are Activated to Cytotoxic Alkylating Agents by Carboxypeptidase G2

The synthesis of three novel prodrugs, 4-amino>benzoyl-L-glutamic acid (7), 4-amino>benzoyl-L-glutamic acid (8), and 4-benzoyl-L-glutamic acid (9), for use as anticancer ag