3087-14-7

Usage

Bicyclic heterocyclic compound

Derived from cyclopenta[d]pyrimidin-4-one

Sulfur-containing compound

Has a methylsulfanyl group attached to the ring
Belongs to the class of organic compounds known as pyrimidines
Used in organic synthesis and medicinal chemistry
Potential applications in pharmaceuticals and therapeutic agent development due to unique structural and chemical properties.

Upstream product

• 35563-27-0 2-sulfanylidene-1,2,3,4,6,7-hexahydro-5H-cyclopenta[d]pyrimidin-4-one 
• 74-88-4 methyl iodide 
• 611-10-9 2-ethoxycarbonyl-1-cyclopentanone 
• 2986-19-8 carbamimidothioic acid methyl ester 
• 10472-24-9 methyl 2-oxocyclopentane-1-carboxylate 
• 120-92-3 cyclopentanone 
• 77766-02-0 4-amino-2-methylthio-5,6-trimethylenepyrimidine 
• 147895-43-0 S-methylisothiourea hemisulphate 
• 14527-26-5 2-methylisothiourea sulphate 

Downstream Products

• 51660-15-2 4-chloro-2-(methylthio)-6,7-dihydro-5H-cyclopenta[d]pyrimidine 
• 5466-00-2 6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diol 
• 5466-43-3 2,4-dichloro-6,7-dihydro-5H-cyclopentapyrimidine 
• 5466-00-2 1,5,6,7-tetrahydro-cyclopentapyrimidine-2,4-dione 
• 7511-98-0 2-methylsulfanyl-3,5,6,7-tetrahydro-cyclopentapyrimidine-4-thione 
• 791734-57-1 2-(4-benzyl-1-piperazinyl)-4-methylamino-5,6-trimethylenepyrimidine 
• 78043-15-9 2-(4-benzyl-1-piperazinyl)-4-chloro-5,6-trimethylenepyrimidine 
• 79051-07-3 2-(4-benzyl-1-piperazinyl)-5,6-trimethylene-4(3H)-pyrimidinone 
• 4344-74-5 1,2,3,4,5,6-hexahydro-cyclopentapyrazol-3-on 
• 905086-67-1 2-(4-chloro-anilino)-3,5,6,7-tetrahydro-cyclopentapyrimidin-4-one 
• 33017-96-8 2-morpholin-4-yl-3,5,6,7-tetrahydro-cyclopentapyrimidin-4-one 

Relevant academic research and scientific papers

Synthetic method of medical intermediate cycloalkanopyrimidinedione compound

The invention provides a synthetic method of a cycloalkanopyrimidinedione compound, and belongs to the technical field of organic synthesis. The method provided by the invention comprises the following steps of: taking a 2-methoxycarbonyl naphthenone comp

HETEROARYL DERIVATIVES AS SEPIAPTERIN REDUCTASE INHIBITORS

Inhibitors of sepiapterin reductase of formula (I) or (I'), wherein the substituents are defined as in the claims, and uses of sepiapterin reductase inhibitors in analgesia, treatment of acute and chronic pain, anti-inflammation, and immune cell regulation are disclosed.

BICYCLIC DERIVATIVE CONTAINING PYRIMIDINE RING, AND PREPARATION METHOD THEREFOR

The present invention provides: a bicyclic derivative comprising a pyrimidine ring, or a pharmaceutically acceptable salt thereof; a preparation method therefor, a pharmaceutical composition comprising the same; and a use therefor. According to the present invention, the bicyclic compound derivative comprising a pyrimidine ring, or a pharmaceutically acceptable salt thereof acts as a 5-HT4 receptor agonist, and thus can be usefully applied to the prevention or treatment of dysfunction in gastrointestinal motility, for example, gastrointestinal diseases such as gastroesophageal reflux disease (GERD), constipation, irritable bowel syndrome (IBS), dyspepsia, post-operative ileus, delayed gastric emptying, gastroparesis, intestinal pseudo-obstruction, drug-induced delayed transit, diabetic gastric atony and the like.

Cyclopentyl-pyrimidine based analogues as novel and potent IGF-1R inhibitor

A series of novel 2-amino-4-pyrazolecyclopentylpyrimidines have been prepared and evaluated as IGF-1R tyrosin kinase inhibitors. The in vitro activity was found to depend strongly on the substitution pattern in the 2-amino ring, 4-pyrazolo moieties and size of fused saturated ring with the central pyrimidine core. A stepwise optimization by combination of active fragments led to discovery of compound 6f and 6k, two structures with IGF-1R IC50 of 20 nM and 10 nM, respectively. 6f was further profiled for its anti cancer activity across various cell lines and pharmacokinetic studies in Sprague Dawley rats.

Carboxylic acid derivatives, their preparation and use in treating cancer

This invention provides a method for treating cancer in an individual, wherein the cancer is a tumor in which endothelin is upregulated (e.g. tumors of the prostate, lung, liver, breast, brain, stomach, colon, endometrium, testicle, thyroid, pituatary, bladder, kidney, pancreas and meninges) by administering to the individual an effective amount of a compound of Formula I or Formula Ia, as describe herein.

Pyrimidine Derivatives. II. New Synthesis and Reactions of 4-Amino-2-methylthiopyrimidine Derivatives

4-Amino-2-methylthiopyrimidine derivatives (4) were synthesized by the cyclization of 3-cyano-2-methylisothiourea (2) with ketones (3).Oxidation of 4 produced 4-amino-2-methylsulfinyl or 2-methylsulfonylpyrimidine derivatives (7 or 8).Amination of 7 or 8 gave hypoglycemic 2-(1-piperazinyl)pyrimidines (1).Compounds 4 were converted to 4(3H)-pyrimidinone derivatives (12).Derivatives 1 were also synthesized via 12.Keywords - hypoglycemic drug; base-catalyzed cyclization; 3-cyano-2-methylisothiourea; 4-amino-2-methylthiopyrimidines; 4-amino-2-methylthio-5,6,7,8-tetrahydroquinazoline; 2-methylthio-4(3H)-pyrimidinones; 2-methylsulfinylpyrimidines amination; 2-methylsulfonylpyrimidines amination