308815-40-9Relevant academic research and scientific papers
Pyrrolidine-2,4-diones with affinity to the N-methyl-D-aspartate (glycine site) receptor. Part II: 5-Arylidene-pyrrolidine-2,3,4-trione 3- oximes as NMDA receptor antagonists
Poschenrieder, Hermann,Hoefner, Georg,Stachel, Hans-Dietrich
, p. 309 - 316 (1999)
A series of oximes deriving from 5-arylidene-pyrrolidine-2,3,4-triones and pyridine-2,3,4-triones has been prepared. The presence of the tautomeric nitrosoenol was proven in solutions of α-ketooxime 7a. The binding affinity of the new oximes toward the N-methyl-D-aspartate (glycine site) receptor has been measured as a basis for more detailed structure-activity relationship studies. Oxime 13b showed the highest binding potency acting as glycine antagonist in nanomolar concentration.
