308816-06-0Relevant academic research and scientific papers
Synthesis and biological evaluation of structurally highly modified analogues of the antimitotic natural product curacin A
Wipf, Peter,Reeves, Jonathan T.,Balachandran, Raghavan,Day, Billy W.
, p. 1901 - 1917 (2007/10/03)
Structure-activity relationship analysis of synthetic analogues of curacin A revealed the lack of activity of traditional heterocyclic replacements of the thiazoline ring or cyclopropyl analogues of the core diene segment. The significance of the C(3)-C(4
Synthesis and biological evaluation of a focused mixture library of analogues of the antimitotic marine natural product curacin A
Wipf, Peter,Reeves, Jonathan T.,Balachandran, Raghavan,Giuliano, Kenneth A.,Hamel, Ernest,Day, Billy W.
, p. 9391 - 9395 (2007/10/03)
The marine natural product curacin A served as the lead compound for the combinatorial synthesis of 6-compound mixture libraries. Fluorous trapping with a vinyl ether tag was used to streamline purification of the heterogeneous multicomponent reaction pro
