3092-22-6Relevant academic research and scientific papers
Synthesis and anticonvulsant activity of new 6-methyl-1-substituted-4,6- diazaspiro[2.4]heptane-5,7-diones
He, Xianran,Qiu, Guanpeng,Yang, Jin,Xiao, Yuling,Wu, Zhongyuan,Qiu, Guofu,Hu, Xianming
experimental part, p. 3818 - 3830 (2010/09/10)
In the present study on the development of new anticonvulsants, twenty new 6-methyl-1-substituted-4,6-diazaspiro[2.4]heptane-5,7-diones were synthesized and tested for anticonvulsant activity using the maximal electroshock (MES) and subcutaneous pentylene
Novel N-substituted 2-phenyl-1-sulfonylamino-cyclopropane carboxylates as selective ADAMTS-5 (Aggrecanase-2) inhibitors
Shiozaki, Makoto,Maeda, Katsuya,Miura, Tomoya,Ogoshi, Yosuke,Haas, Julia,Fryer, Andrew M.,Laird, Ellen R.,Littmann, Nicole M.,Andrews, Steven W.,Josey, John A.,Mimura, Takayuki,Shinozaki, Yuichi,Yoshiuchi, Hiromi,Inaba, Takashi
scheme or table, p. 1575 - 1580 (2009/12/07)
A series of N-substituted sulfonylamino-alkanecarboxylate ADAMTS-5 (Aggrecanase-2) inhibitors has been synthesized and the in vitro enzyme SAR is discussed. This report is the first example of carboxylate-based ADAMTS-5 inhibitors which show strong potenc
