309253-79-0Relevant academic research and scientific papers
Mild and efficient functionalization at C6 of purine 2′-deoxynucleosides and ribonucleosides
Lin, Xiaoyu,Robins, Morris J.
, p. 3497 - 3499 (2000)
(Equation Presented) Treatment of sugar-protected inosine and 2′-deoxyinosine derivatives with a cyclic secondary amine or imidazole and I2/Ph3P/EtN(i-Pr)2/(CH2-Cl 2 or toluene) gave quantitative conversions into 6-N-(substituted)purine nucleosides. SNAr reactions with (imidazol-1-yl) derivatives gave 6-(N, O, or S)-substituted products. The 6-(benzylsulfonyl) group underwent SNAr displacement with an arylamine at ambient temperature.
