30929-57-8

Basic information

• Product Name: CYCLOHEXYLHYDRAZINE DIHYDROCHLORIDE
• Synonyms: CYCLOHEXYLHYDRAZINE DIHYDROCHLORIDE
• CAS NO: 30929-57-8
• Molecular Formula: C6H16Cl2N2
• Molecular Weight: 187.11
• Mol File: 30929-57-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 210.9°Cat760mmHg
• Flash Point: 91.7°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 0.00198mmHg at 25°C
• CAS DataBase Reference: CYCLOHEXYLHYDRAZINE DIHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLOHEXYLHYDRAZINE DIHYDROCHLORIDE(30929-57-8)
• EPA Substance Registry System: CYCLOHEXYLHYDRAZINE DIHYDROCHLORIDE(30929-57-8)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 30929-57-8(Hazardous Substances Data)

Usage

General Description

Cyclohexylhydrazine dihydrochloride is a synthetic compound with the chemical formula C6H16N2.HCl2. It is commonly used as a reagent in organic synthesis and as a precursor in the production of pharmaceuticals. This chemical is a white to off-white crystalline powder that is soluble in water and ethanol. Cyclohexylhydrazine dihydrochloride is classified as a hazardous substance and should be handled with caution due to its potential health and environmental risks. It is known to be toxic if ingested, inhaled, or absorbed through the skin, and can cause irritation to the respiratory system and eyes. Additionally, it may pose a risk to aquatic organisms if released into the environment.

InChI:InChI=1/C6H14N2.2ClH/c7-8-6-4-2-1-3-5-6;;/h6,8H,1-5,7H2;2*1H

Upstream product

• 931-51-1 cyclohexylmagnesiumchloride 
• 108-94-1 cyclohexanone 
• 60295-11-6 tert-butyl 2-cyclohexylidenehydrazine-1-carboxylate 
• 60295-21-8 N'-cyclohexyl-hydrazine carboxylic acid tert-butyl ester 

Downstream Products

• 1426534-39-5 C₂₂H₂₆N₂O 
• 1404198-33-9 C₁₃H₁₇N₃S 

Relevant articles and documents

Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators

The present study describes the discovery and characterization of a series of 5-aryl-2H-tetrazol-3-ylacetamides as G protein-gated inwardly-rectifying potassium (GIRK) channels activators. Working from an initial hit discovered during a high-throughput screening campaign, we identified a tetrazole scaffold that shifts away from the previously reported urea-based scaffolds while remaining effective GIRK1/2 channel activators. In addition, we evaluated the compounds in Tier 1 DMPK assays and have identified a (3-methyl-1H-pyrazol-1-yl)tetrahydrothiophene-1,1-dioxide head group that imparts interesting and unexpected microsomal stability compared to previously-reported pyrazole head groups.

PYRAZOLOPYRIMIDINES AS INHIBITORS OF GLUCOCORTICOID RECEPTOR TRANSLOCATION

Provided herein are compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of Glucocorticoid Receptor (GR) translocation. Furthermore, the subject compounds and compositions are useful for the treatment of diseases involved in the hypothalamic-pituitary-adrenal (HPA) axis.

Reactions of grignard reagents with nitrous oxide

The chemical activation of nitrous oxide (N2O) can be achieved by organocalcium, organosodium, and organolithium compounds. Grignard reagents, on the other hand, are believed to be inert. We demonstrate that this generalization is not correct. Some aliphatic Grignard reagents undergo a rapid conversion when subjected to an atmosphere of N2O. Hydrazones are the main reaction products.