30933-69-8

Usage

Uses

Used in Organic Synthesis:
ETHYL 4-BROMO-5-METHOXY-1H-INDOLE-2-CARBOXYLATE is used as a versatile intermediate in organic synthesis for the preparation of various organic compounds. Its unique structure and reactivity make it a valuable building block in the synthesis of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, ETHYL 4-BROMO-5-METHOXY-1H-INDOLE-2-CARBOXYLATE is used as a key intermediate in the development of new drugs. Its potential biological activity and medicinal properties are extensively studied for the discovery of novel therapeutic agents.
Used in Medicinal Chemistry:
ETHYL 4-BROMO-5-METHOXY-1H-INDOLE-2-CARBOXYLATE is employed as a starting material in medicinal chemistry for the design and synthesis of bioactive molecules. Its structural features allow for the development of compounds with potential therapeutic applications.
Used in Drug Discovery:
In drug discovery, ETHYL 4-BROMO-5-METHOXY-1H-INDOLE-2-CARBOXYLATE is used as a scaffold for the development of new pharmaceutical agents. Its unique chemical properties and potential biological activity make it a promising candidate for the creation of innovative therapeutics.
Used in Chemical Research:
ETHYL 4-BROMO-5-METHOXY-1H-INDOLE-2-CARBOXYLATE is utilized in chemical research to explore its reactivity, properties, and potential applications in various chemical processes. Its unique structure and functional groups provide insights into the development of new synthetic methods and strategies.

InChI:InChI=1/C12H12BrNO3/c1-3-17-12(15)9-6-7-8(14-9)4-5-10(16-2)11(7)13/h4-6,14H,3H2,1-2H3

Upstream product

• 4792-58-9 ethyl 5-methoxy-1H-indole-2-carboxylate 
• 128593-38-4 2-[(3-Bromo-4-methoxy-phenyl)-hydrazono]-propionic acid ethyl ester 
• 92622-96-3 ethyl 3-bromo-5-methoxy-1H-indole-2-carboxylate 

Downstream Products

• 1215118-56-1 2-(9-chloro-7-(3-cyano-4-isopropoxybenzyloxy)-8-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid 
• 1215119-15-5 ethyl 2-(7-(3-cyano-4-isopropoxybenzyloxy)-8-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate 
• 1215118-55-0 2-(7-(3-cyano-4-isopropoxybenzyloxy)-8-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid 
• 90858-86-9 4-bromo-5-methoxy-1H-indole 
• 92623-00-2 5-methoxyindole-4-carboxaldehyde 
• 92622-97-4 4-bromo-5-methoxy-1H-indole-2-carboxylic acid 

Relevant academic research and scientific papers

SUBSTITUTED TRICYCLIC ACID DERIVATIVES AS S1P1 RECEPTOR AGONISTS USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS

The present invention relates to certain substituted tricyclic acid derivatives of Formula (I) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the S1P1 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of S1P1-associated disorders, for example, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type I diabetes, acne, myocardial ischemia-reperfusion injury, hypertensive nephropathy, glomerulosclerosis, gastritis, polymyositis, thyroiditis, vitiligo, hepatitis, biliary cirrhosis, microbial infections and associated diseases, viral infections and associated diseases, diseases and disorders mediated by lymphocytes, auto immune diseases, inflammatory diseases, and cancer.

Palladium-Catalyzed Regioselective Hydrodebromination of Dibromoindoles: Application to the Enantioselective Synthesis of Indolodioxane U86192A

A novel approach to the selective preparation of 4-bromoindoles was developed via Pd(OAc)2/rac-BINAP catalytic reactions. A variety of 4,6-dibromoindoles were transformed to 4-bromoindoles with high regioselectivity. This methodology, along wit

REGIOSELECTIVE BROMINATION OF METHOXY DERIVATIVES OF ETHYL INDOLE-2-CARBOXYLATE

Bromination of ethyl methoxyindole-2-carboxylate (1) with bromine in acetic acid proceeded on the benzene moiety of 1, whereas the reaction of 1 with pyridinium bromide perbromide in pyridine or N-bromosuccinimide in dimethylformamide gave ethyl 3-bromo-m