30934-62-4

Basic information

• Product Name: 2-(4-(trifluoromethyl)phenyl)acetaldehyde
• Synonyms: 2-(4-(trifluoromethyl)phenyl)acetaldehyde;4-trifluoromethylphenylacetaldehyde
• CAS NO: 30934-62-4
• Molecular Formula: C₉H₇F₃O
• Molecular Weight: 188.14600
• Mol File: 30934-62-4.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 209.878°C at 760 mmHg (Cal.) ref.
• Flash Point: 83.426°C (Cal.) ref.
• Appearance: /
• Density: 1.229g/cm3 (Cal.) ref.
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 2-(4-(trifluoromethyl)phenyl)acetaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-(trifluoromethyl)phenyl)acetaldehyde(30934-62-4)
• EPA Substance Registry System: 2-(4-(trifluoromethyl)phenyl)acetaldehyde(30934-62-4)

Safety Data

• Hazardous Substances Data: 30934-62-4(Hazardous Substances Data)

Upstream product

• 721-63-1 (4-trifluoromethylphenyl)acetic acid ethyl ester 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 402-50-6 1-trifluoromethyl-4-vinyl-benzene 
• 135325-18-7 methyl 2-(4-(trifluoromethyl)phenyl)acetate 
• 32857-62-8 4-Trifluoromethylphenylacetic acid 
• 1813-97-4 1-allyl-4-(trifluoromethyl)benzene 
• 2968-93-6 2-(4-trifluoromethylphenyl)ethanol 
• 30993-34-1 2-[(4-trifluoromethyl)benzyl]-1,3-dioxolane 

Downstream Products

• 184360-95-0 (E)-4-((p-trifluoromethyl)phenyl)but-3-enoic acid 
• 1065495-75-1 (Z)-N-(2-propynyl)-N'-[2-(4-trifluoromethylphenyl)ethylidene]hydrazine 
• 1065495-55-7 (E)-N-(2-propynyl)-N'-[2-(4-trifluoromethylphenyl)ethylidene]hydrazine 
• 1093877-83-8 C₁₈H₁₄F₃N₃OS 
• 590417-82-6 1-[4-(trifluoromethyl)phenyl]propan-2-ol 
• 1438389-21-9 (E)-4-(trifluoromethyl)styryl acetate 
• 1527491-78-6 (Z)-4-(trifluoromethyl)styryl acetate 

Relevant articles and documents

COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY

The present invention relates to chemical entities (for example, a pharmaceutically acceptable compound or salt, and / or a hydrate, and / or a co-crystal, and / or a combination of drug of the compound) which inhibit (for example, antagonize) the stimula

Regioselective, Diastereoselective, and Enantioselective One-Pot Tandem Reaction Based on an in Situ Formed Reductant: Preparation of 2,3-Disubstituted 1,5-Benzodiazepine

The 1,5-benzodiazepines are important skeletons frequently contained in medicinal chemistry. Herein, we described an unexpected tandem cyclization/transfer hydrogenation reaction for obtaining chiral 2,3-disubstituted 1,5-benzodiazepines. The enolizable aryl aldehydes were chosen as substrates to react with symmetric and unsymmetric o-phenylenediamines. The unforeseen tandem reaction occurred among many possible latent side reactions under chiral phosphoric acid catalysis and affords the corresponding products in moderate yields and regioselectivities, good diastereoselectivities, and enantiomeric ratio (up to 99:1).

Selective N1/N4 1,4-Cycloaddition of 1,2,4,5-Tetrazines Enabled by Solvent Hydrogen Bonding

An unprecedented 1,4-cycloaddition (vs 3,6-cycloaddition) of 1,2,4,5-tetrazines is described with preformed or in situ generated aryl-conjugated enamines promoted by the solvent hydrogen bonding of hexafluoroisopropanol (HFIP) that is conducted under mild reaction conditions (0.1 M HFIP, 25 °C, 12 h). The reaction constitutes a formal [4 + 2] cycloaddition across the two nitrogen atoms (N1/N4) of the 1,2,4,5-tetrazine followed by a formal retro [4 + 2] cycloaddition loss of a nitrile and aromatization to generate a 1,2,4-triazine derivative. The factors that impact the remarkable change in the reaction mode, optimization of reaction parameters, the scope and simplification of its implementation through in situ enamine generation from aldehydes and ketones, the reaction scope for 3,6-bis(thiomethyl)-1,2,4,5-tetrazine, a survey of participating 1,2,4,5-tetrazines, and key mechanistic insights into this reaction are detailed. Given its simplicity and breath, the study establishes a novel method for the simple and efficient one-step synthesis of 1,2,4-triazines under mild conditions from readily accessible starting materials. Whereas alternative protic solvents (e.g., MeOH vs HFIP) provide products of the conventional 3,6-cycoladdition, the enhanced hydrogen bonding capability of HFIP uniquely results in promotion of the unprecedented formal 1,4-cycloaddition. As such, the studies represent an example of not just an enhancement in the rate or efficiency of a heterocyclic azadiene cycloaddition by hydrogen bonding catalysis but also the first to alter the mode (N1/N4 vs C3/C6) of cycloaddition.