30948-17-5

Usage

Uses

Used in Industrial Applications:
5-Oxo-pyrrolidine-3-carboxylic acid is used as a chemical intermediate for the synthesis of various industrial products. Its unique structure allows it to be a potential building block for the development of new materials and compounds.
Used in Pharmaceutical Applications:
5-Oxo-pyrrolidine-3-carboxylic acid is used as a starting material in the synthesis of pharmaceutical compounds. Its chemical properties may contribute to the development of new drugs with potential therapeutic applications.
Used in Research Applications:
5-Oxo-pyrrolidine-3-carboxylic acid is used as a research compound in academic and scientific studies. Its unique structure and properties make it an interesting subject for exploration in various fields of chemistry and related disciplines.

Upstream product

• 35309-35-4 5-oxopyrrolidine-3-carboxylic acid methyl ester 

Downstream Products

• 1426404-45-6 (S)-5-oxopyrrolidine-3-carboxylic acid {1-(4-fluorophenyl)-5-[3-((R)-2,2,2-trifluoro-1-methylethoxymethyl)phenyl]-1H-pyrazol-3-yl}amide 
• 1426404-44-5 (S)-5-oxopyrrolidine-3-carboxylic acid {1-(2-fluorophenyl)-5-[3-fluoro-5-((R)-2,2,2-trifluoro-1-methylethoxymethyl)phenyl]-1H-pyrazol-3-yl}amide 
• 1426404-42-3 (S)-5-oxopyrrolidine-3-carboxylic acid {5-[3-fluoro-5-((R)-2,2,2-trifluoro-1-methylethoxymethyl)phenyl]-1-phenyl-1H-pyrazol-3-yl}amide 
• 428518-31-4 methyl (S)-(-)-5-oxo-3-pyrrolidinecarboxylate 

Relevant academic research and scientific papers

A chemoenzymatic approach to the synthesis of enantiomerically pure aza analogues of paraconic acid methyl ester and both enantiomers of methyl β-proline

Enantiopure methyl esters of 1-alkyl-5-oxo-3-pyrrolidinecarboxylic acids were obtained by enzymatic resolution of the corresponding chiral racemic mixtures. A particularly favourable interaction, also supported by molecular mechanics calculations, was observed between the 1-benzyl derivative and α-chymotrypsin, for which the enantiomeric ratio, E, exceeded 200. The absolute configurations of the lactams were determined by means of CD spectroscopy. From the resulting enantiomerically pure (99% e.e.) (S)-(+)-1-benzyl-3-pyrrolidinecarboxylic acid and methyl (R)-(-)-1-benzyl-3-pyrrolidinecarboxylate, the methyl esters of (+) and (-)-β-proline were synthesised in 99% e.e. and 18 and 22% overall yield, respectively.