30962-73-3Relevant academic research and scientific papers
Pyrido[3,4-e]-1,2,4-triazines and related heterocycles as potential antifungal agents
Reich,Fabio,Lee,Kuck,Testa
, p. 2474 - 2485 (2007/10/02)
The preparation and biological activities of a series of pyrido[3,4-e]-1,2,4-triazines, 1,2,4-triazino[5,6-c]quinolines, and related fused triazines are described. Methyl, amino, and acylamino substituents were placed in the pyridyl ring of the former system. Other structural modifications included various alkyl, cycloalkyl, substituted phenyl, and heterocyclic groups in the 3-position of these ring systems. In agar dilution assays, actives in this series inhibited strains of Candida, Aspergillus, Mucor, and Trychophyton species at MIC's of ≤ 16 μg/mL.
