309726-06-5Relevant academic research and scientific papers
Preparation method and application of 5-aminobenzene[b][1,8]naphthyridine compound
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Paragraph 0045-0046; 0051-0052, (2019/10/17)
The invention belongs to the field of pharmaceutical chemistry, and specifically provides a preparation method and application of a 5-aminobenzene[b][1,8]naphthyridine compound. The preparation methodis a route for synthesis of the 5-aminobenzene [b][1,8] naphthalidine compound by intramolecular cyclization of a molecule of a 4,6-2-disubstituted-2-Naryl-3nitrile compound catalyzed by trifluoro-methanesulfonic acid, more 5-aminobenzene[b][1,8]naphthalidine compounds can be prepared, and the prepared compounds show good antitumor activity in vitro.
