309747-36-2Relevant academic research and scientific papers
CHEMICAL COMPOUNDS
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Page/Page column 155-156, (2010/11/04)
The invention is directed to to substituted indazole derivatives. Specifically, the invention is directed to compounds according to Formula I: wherein R1 - R6 and X are defined herein. The compounds of the invention are inhibitors of PDK1 and can be useful in the treatment of disorders characterized by constitutively activated ACG kinases such as cancer and more specifically leukemia and cancers of the breast, colon, and lung. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting PDK1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
Investigation of platelet aggregation inhibitory activity by phenyl amides and esters of piperidinecarboxylic acids
De Candia, Modesto,Summo, Luciana,Carrieri, Antonio,Altomare, Cosimo,Nardecchia, Adele,Cellamare, Saverio,Carotti, Angelo
, p. 1439 - 1450 (2007/10/03)
A series of anilides and phenyl esters of piperidine-3-carboxylic acid (nipecotic acid) were synthesized and tested for the ability to inhibit aggregation of human platelet rich-plasma triggered by adenosine 5′-diphosphate (ADP) and adrenaline. As a rule,
