309756-87-4Relevant academic research and scientific papers
Asymmetric synthesis and chromatographic resolution of all four stereomers of the α,β-propanoleucine
Bisel,Breitling,Schlauch,Volk,Frahm
, p. 770 - 772 (2007/10/03)
The paper describes the first synthesis of the enantiomerically pure cis-α,β-propanoleucines 6c and 6d by means of asymmetric Strecker synthesis. Furthermore, an improved procedure for the preparation of the stereomeric trans compounds 6a and 6b is proposed. Finally, the four feasible stereomeric α,α-quaternary-α-amino acids are resolved on a penicillamine based chiral stationary phase allowing the determination of ee values ranging from 92.9% to > 98%.
Carbocyclic α-amino acids: Asymmetric Strecker synthesis of a series of 2-alkylated 1-aminocyclopentanecarboxylic acids
Wede, Judith,Volk, Franz-J.,Frahm, August W.
, p. 3231 - 3252 (2007/10/03)
A series of 12 carbocyclic α-amino acids has been prepared from four different racemic 2-alkylated cyclopentanones and (R)-1-phenylethylamine as the chiral auxiliary by means of an asymmetric Strecker synthesis. The stereoselectivity was influenced by sol
