30982-21-9Relevant academic research and scientific papers
Application of microwaves in organic synthesis: A rapid and efficient synthesis of new 3-aryl-2-imino-4-methyl-2,5-dihydrofurans and 3-aryl-3-2-(5H)-furanones
Villemin, Didier,Liao, Liang
, p. 1575 - 1585 (2003)
New 3-aryl-2-imino-4-methyl-2,5-dihydrofurans (3a-f) were efficiently synthesized by a one-pot condensation under focused microwave irradiation from simple and readily available starting materials. Hydrolysis of (3a-f) gave 3-aryl-4-methyl-2-(5H)-furanones (4a-f).
Copper-Catalyzed [2 + 3] Cyclization of α-Hydroxyl Ketones and Arylacetonitriles: Access to Multisubstituted Butenolides and Oxazoles
Qi, Chaorong,Peng, Youbin,Wang, Lu,Ren, Yanwei,Jiang, Huanfeng
, p. 11926 - 11935 (2018/09/25)
A copper-catalyzed [2 + 3] formal cyclization reaction between α-hydroxyl ketones and arylacetonitriles has been developed. The reaction outcome was ultimately dependent on the structure of the α-hydroxy ketones employed. Tertiary α-hydroxy ketones gave 3,4,5,5-tetrasubstituted butenolides as the sole products, while secondary α-hydroxy ketones furnished 2,4,5-trisubstituted oxazoles selectively. This method has many advantages, such as the use of easily available substrates, broad substrate scope, good functional tolerance, and milder reaction conditions.
