3099-82-9Relevant academic research and scientific papers
Ketohydrazone dyes derived from 4-morpholino-2-naphthol and ortho-substituted anilines: Further examination of the hyperchromism induced by the 4-morpholino-2-naphthol moiety
Aiken, Stuart,Gabbutt, Christopher. D.,Heron, B. Mark,Pinnington, Daniel. G.
, (2021/08/10)
A series of ketohydrazone dyes has been synthesised from 4-morpholino-2-naphthol and ortho-substituted anilines by conventional diazotisation coupling chemistry. Whilst the new, dull orange-red, dyes exhibit only a minor variation of absorption maxima acr
Synthesis of some new Pyridine-based Heterocyclic Compounds with Anticipated Antitumor Activity
Gomha, Sobhi M.,Abdelrazek, Fathy M.,Abdelrahman, Aly H.,Metz, Peter
, p. 1729 - 1737 (2018/07/25)
A novel class of 5-amino-N′-(1-(pyridin-4-yl)ethylidene)-1H-pyrazole-4-carbohydrazides and 8-(pyridin-4-yl)pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-ones was synthesized from reaction of 2-cyano-N′-(1-(pyridin-4-yl)ethylidene)-acetohydrazide and
Synthesis and structure-activity relationships of 6-heterocyclic- substituted purines as inactivation modifiers of cardiac sodium channels
Estep,Josef,Bacon,Carabateas,Rumney IV,Pilling,Krafte,Volberg,Dillon,Dugrenier,Briggs,Canniff,Gorczyca,Stankus,Ezrin
, p. 2582 - 2595 (2007/10/02)
Purine-based analogs of SDZ 211-500 (5) were prepared and evaluated as inactivation modifiers of guinea pig or human cardiac sodium (Na) channels expressed in Xenopus oocytes. Substances which remove or slow the Na channel inactivation process in cardiac tissue are anticipated to prolong the effective refractory period and increase inotropy and thus have potential utility as antiarrhythmic agents. Heterocyclic substitution at the 6-position of the purine ring resulted in compounds with increased Na activity and potency, with 5-membered heterocycles being optimal. Only minor modifications to the benzhydrylpiperazine side chain were tolerated. Selected compounds which delayed the inactivation of Na channels were found to increase refractoriness and contractility in a rabbit Langendorff heart model, consistent with the cellular mechanism. Activity in both the oocyte and rabbit heart assays was specific to the S enantiomers. Preliminary in vivo activity has been demonstrated following intravenous infusion. The most promising compound on the basis of in vitro data is the formylpyrrole (S)74, which is 25-fold more potent than DPI 201-106 (1) in the human heart Na channel assay.
SYNTHESIS AND REACTIONS OF 4,5-DIARYL-2-MERCAPTOIMIDAZOLES
Salama, M. A.,Yousif, N. M.,Hammam, A. G.
, p. 83 - 88 (2007/10/02)
4,5-Diaryl-2-mercaptoimidazoles (II) were synthesized and reacted with chloroacetic acid to form the S-carboxymethyl derivatives (III).The latter compounds were readily cyclised into the corresponding 5,6-diaryl-2,3-dihydroimidazo(2,1-b) thiazol-3-ones (I
