309947-86-2

Basic information

• Product Name: di-tert-butyl 9H-purin-6-yliMidodicarbonate
• Synonyms: di-tert-butyl 9H-purin-6-yliMidodicarbonate;IMidodicarbonic acid, 2-(9H-purin-6-yl)-, 1,3-bis(1,1-diMethylethyl) ester;tert-Butyl N-tert-butoxycarbonyl-N-(7H-purin-6-yl)carbamate;tert-butyl N-[(2-methylpropan-2-yl)oxycarbonyl]-N-(7H-purin-6-yl)carbamate;tert-butyl N-[(tert-butoxy)carbonyl]-N-(9H-purin-6-yl)carbamate
• CAS NO: 309947-86-2
• Molecular Formula: C₁₅H₂₁N₅O₄
• Molecular Weight: 335.35834
• Mol File: 309947-86-2.mol
• Article Data: 14

Chemical Properties

• Melting Point: 149-150 °C
• Boiling Point: 500.5±53.0 °C(Predicted)
• Appearance: /
• Density: 1.296±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 9.59±0.10(Predicted)
• CAS DataBase Reference: di-tert-butyl 9H-purin-6-yliMidodicarbonate(CAS DataBase Reference)
• NIST Chemistry Reference: di-tert-butyl 9H-purin-6-yliMidodicarbonate(309947-86-2)
• EPA Substance Registry System: di-tert-butyl 9H-purin-6-yliMidodicarbonate(309947-86-2)

Safety Data

• Hazardous Substances Data: 309947-86-2(Hazardous Substances Data)

Usage

General Description

Di-tert-butyl 9H-purin-6-yliMidodicarbonate is a chemical compound with the molecular formula C18H26N8O6. It is a derivative of purine, a nitrogenous base commonly found in DNA and RNA. di-tert-butyl 9H-purin-6-yliMidodicarbonate is used in organic chemistry as a reagent for the protection of nucleobases during the synthesis of nucleosides. Its di-tert-butyl groups provide steric hindrance, making it useful for selective protection of specific functional groups during chemical reactions. Additionally, di-tert-butyl 9H-purin-6-yliMidodicarbonate has been studied for its potential pharmacological properties, particularly as a potential antitumor agent due to its ability to interfere with DNA replication and repair processes.

Upstream product

• 73-24-5 7H-purin-6-ylamine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 66224-66-6 adenine 
• 309947-84-0 tert-butyl 6-[bis(tert-butoxycarbonyl)amino]-9H-purine-9-carboxylate 

Downstream Products

• 952418-11-0 (1R,4R,5S)-9-[3-(tert-butyldiphenylsilyloxymethyl)-4,5-isopropylidenedioxy-2-cyclopenten-1-yl]-N⁶,N⁶-bis(tert-butoxycarbonyl)adenine 

Relevant articles and documents

Synthesis of Rigid Rod, Trigonal, and Tetrahedral Nucleobase-Terminated Molecules

An efficient fragment splicing method for the construction of multiple nucleobase-terminated monomers has been developed. Conformationally fixed rod, trigonal planar and tetrahedral thymine and adenine structures were generated in moderate to good yields,

MLL1 INHIBITORS AND ANTI-CANCER AGENTS

The present invention provides a compound of Formula (I): or an enantiomer, an enantiomeric mixture, or a pharmaceutically acceptable salt thereof; wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds; and methods of using such compounds for treating a disease or condition mediated by mixed lineage leukemia 1 (MLL).

MLL1 INHIBITORS AND ANTI-CANCER AGENTS

The present invention provides a compound of Formula (I): or an enantiomer, an enantiomeric mixture, or a pharmaceutically acceptable salt thereof; wherein the variables are as defined herein. The present invention further provides pharmaceutical composit