309962-67-2

Basic information

• Product Name: (R)-3-N-Boc-3-(methylamino)piperidine
• Synonyms: (R)-3-N-Boc-3-(methylamino)piperidine;(R)-TERT-BUTYLMETHYL(PIPERIDIN-3-YL)CARBAMATE;(R)-3-Boc-3-(Methylamino)piperidine;(R)-tert-butyl piperidin-3-ylMethylcarbaMate;Methyl(3R)-3-piperidinylcarbamic acid tert-butyl ester;(R)-3-(N-Boc-MethylaMino)piperidine;tert-butyl (R)-methyl(piperidin-3-yl)carbamate;tert-butyl N-methyl-N-[(3R)-piperidin-3-yl]carbamate
• CAS NO: 309962-67-2
• Molecular Formula: C₁₁H₂₂N₂O₂
• Molecular Weight: 214.31
• Mol File: 309962-67-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 288℃
• Flash Point: 128℃
• Appearance: /
• Density: 1.01
• Vapor Pressure: 0.00242mmHg at 25°C
• Refractive Index: 1.485
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: (R)-3-N-Boc-3-(methylamino)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-N-Boc-3-(methylamino)piperidine(309962-67-2)
• EPA Substance Registry System: (R)-3-N-Boc-3-(methylamino)piperidine(309962-67-2)

Safety Data

• Hazardous Substances Data: 309962-67-2(Hazardous Substances Data)

Usage

Description

(R)-3-N-Boc-3-(methylamino)piperidine is a piperidine derivative characterized by a tertiary amine group and a Boc (tert-butoxycarbonyl) protective group on the nitrogen atom. The molecule has a chiral center, with the (R)-stereoisomer indicating its specific configuration. (R)-3-N-Boc-3-(methylamino)piperidine is a valuable building block in organic synthesis, particularly for the preparation of pharmaceutical intermediates and ligands for asymmetric catalysis.

Uses

Used in Pharmaceutical Industry:
(R)-3-N-Boc-3-(methylamino)piperidine is used as a pharmaceutical intermediate for the synthesis of various nitrogen-containing compounds. Its Boc protective group provides stability to the amine functionality, making it suitable for the development of new drugs and therapeutic agents.
Used in Organic Synthesis:
(R)-3-N-Boc-3-(methylamino)piperidine is used as a building block in organic synthesis for the preparation of a wide range of nitrogen-containing compounds. The presence of the methylamino group adds functionality and versatility to the molecule, enabling it to participate in various chemical transformations.
Used in Asymmetric Catalysis:
(R)-3-N-Boc-3-(methylamino)piperidine is used as a ligand in asymmetric catalysis, where its chiral center plays a crucial role in the selective formation of enantiomerically pure products. This application is particularly relevant in the synthesis of chiral pharmaceuticals and agrochemicals, where enantioselectivity is essential for biological activity and safety.

InChI:InChI=1/C11H22N2O2/c1-11(2,3)15-10(14)13(4)9-6-5-7-12-8-9/h9,12H,5-8H2,1-4H3/t9-/m1/s1

Upstream product

• 485820-12-0 (R)-3-(tert-butoxycarbonylamino)piperidine-1-carboxylic acid benzyl ester 
• 309956-78-3 (R)-piperidin-3-ylcarbamic acid tert-butyl ester 
• 1124199-23-0 (R)-benzyl 3-(tert-butoxycarbonyl(methyl)amino)piperidine-1-carboxylate 

Relevant articles and documents

PYRROLOPYRIDINES AS KINASE INHIBITORS

Compounds of Formula (I) are useful for inhibition of CHKl and/or CHK2. Methods of using compounds of Formula (I) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Heterocyclic substituted aminoazacycles useful as central nervous system agents

Heterocyclic substituted aminoazacyclic compounds of the formula (I):Z-R3, wherein Z is a defined aminoazacycle and R3 is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.