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Cyclohexaneacetic acid, α-fluoro-1-hydroxy, ethyl ester is a chemical compound with the molecular formula C9H15FO3. It is an ester derivative of cyclohexaneacetic acid, featuring a fluorine atom at the α-position and a hydroxyl group at the 1-position. The ethyl ester group is attached to the carboxylic acid moiety, enhancing its reactivity and solubility. Cyclohexaneacetic acid, a-fluoro-1-hydroxy-, ethyl ester is primarily used in the synthesis of pharmaceuticals and agrochemicals, particularly as an intermediate in the production of various drugs and pesticides. Its unique structure and properties make it a valuable component in the development of new chemical entities with potential therapeutic or pesticidal applications.

310-36-1

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310-36-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 310-36-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,1 and 0 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 310-36:
(5*3)+(4*1)+(3*0)+(2*3)+(1*6)=31
31 % 10 = 1
So 310-36-1 is a valid CAS Registry Number.

310-36-1Relevant academic research and scientific papers

Ethyl α-fluoro silyl enol ether: Stereoselective synthesis and its aldol reaction with aldehydes and ketones

Huang, Xiao-Ting,Chen, Qing-Yun

, p. 3231 - 3234 (2007/10/03)

Ethyl α-fluoro silyl enol ether is stereoselectively synthesized in high yield from inexpensive chlorofluoroacetate and Mg (or Zn) in DMF (or HMPA). Lewis acid promoted aldol reaction of this enol ether with aldehydes and ketones gives α-fluoro-β-hydroxy

Catalyzed reformatsky reactions with ethyl bromofluoroacetate for the synthesis of α-fluoro-β-hydroxy acids

Ocampo,Dolbier, Jr.,Abboud,Zuluaga

, p. 72 - 78 (2007/10/03)

The presence of catalytic amounts of CeCl3 improves yields and simplifies procedure in the Reformatsky reactions of ethyl bromofluoroacetate with aldehydes and ketones to generate diastereomeric mixtures of α-fluoro-β-hydroxy esters, some of which can be separated by crystallization or column flash chromatography. Diastereomerically pure α-fluoro-β-hydroxy acids are obtained by mild alkaline hydrolysis of the resolved α-fluoro-β-hydroxy esters. Detailed NMR data of new α-fluoro-β-hydroxy esters and α-fluoro-β-hydroxy acids are also presented.

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