31008-09-0Relevant academic research and scientific papers
Synthesis, DNA and protein interactions and human topoisomerase inhibition of novel Spiroacridine derivatives
Gouveia, Rawny Galdino,Ribeiro, Amélia Galdino,Segundo, Miguel ?ngelo Santos Pinheiro,de Oliveira, Jamerson Ferreira,de Lima, Maria do Carmo Alves,de Lima Souza, Túlio Ricardo Couto,de Almeida, Sinara M?nica Vitalino,de Moura, Ricardo Olímpio
, p. 5911 - 5921 (2018)
Nine new spiroacridine derivatives were synthetized by introducing cyano-N-acylhydrazone group between the acridine and phenyl-substituted rings followed by spontaneous cyclization. The new compounds were assayed for their DNA binding properties, human to
7-Amino-2-aryl/hetero-aryl-5-oxo-5,8-dihydro[1,2,4]triazolo[1,5-a]pyridine-6-carbonitriles: Synthesis and adenosine receptor binding studies
Shaik, Khasim,Deb, Pran Kishore,Mailavaram, Raghu Prasad,Chandrasekaran, Balakumar,Kachler, Sonja,Klotz, Karl-Norbert,Jaber, Abdul Muttaleb Yousef
, p. 1568 - 1573 (2019/05/27)
A series of novel 7-amino-5-oxo-2-substituted-aryl/hetero-aryl-5,8-dihydro[1,2,4]triazolo[1,5-a]pyridine-6-carbonitriles (4a–4t) was synthesized, characterized and evaluated for their binding affinity and selectivity towards hA1, hA2A/sub
