31037-33-9Relevant academic research and scientific papers
Practical selective monohydrolysis of bulky symmetric diesters: Comparing with sonochemistry
Shi, Jianjun,Zhao, Tian,Niwayama, Satomi
, p. 6815 - 6820 (2018)
The conditions of the practical selective monohydrolysis of symmetric diesters we previously reported have been modified and applied to selective monohydrolysis of bulky symmetric diesters. While ultrasound is generally considered effective for two-phase reactions, its effect actually turned out to be rather marginal. Instead, use of a larger proportion of a polar aprotic co-solvent, DMSO, and aqueous KOH helped enhance the reaction rates and improve the yields of the half-esters. The reactions are simple, mild and practical without special devices.
Highly efficient selective monohydrolysis of dialkyl malonates and their derivatives
Niwayama, Satomi,Cho, Hanjoung,Lin, Chunlei
, p. 4434 - 4436 (2008/12/21)
The highly efficient selective monohydrolysis of symmetric diesters has been applied to monohydrolysis of several dialkyl malonates and their derivatives. The best conditions apply 0.8-1.2 equiv of aqueous KOH with a co-solvent, THF or acetonitrile, at 0 °C. The procedure is highly practical, yielding the corresponding half-esters in high yields in a straightforward manner, without inducing decarboxylation. It was found that the selectivity tends to become higher with increased hydrophobicity.
SYNTHESIS OF HALF ESTERS
-
Page/Page column 17-21; 26, (2009/01/24)
A method for hydrolyzing an ester is provided. In accordance with the method, a compound A is provided which has first and second ester moieties. The compound is reacted in a liquid medium with a base having the formula MaXb,such that the first ester moiety is converted to a carboxyl moiety and the second ester moiety remains, wherein the ratio [Xk-]:[A] in the liquid medium is no greater than 1.6, and wherein k > 0.
