310405-37-9

Upstream product

• 137-43-9 Cyclopentyl bromide 
• 14062-25-0 Ethyl 4-bromophenylacetate 

Downstream Products

• 1082453-57-3 (R/S)-(4-bromophenyl)(cyclopentyl)acetic acid 
• 1380605-62-8 (+/-)-tert-butyl 1-(3-{[2-(4-bromophenyl)-2-cyclopentylacetyl]amino}-4-fluorobenzyl)cyclopropanecarboxylate 
• 1380606-49-4 tert-butyl 1-[3-(2S)-(2-{[4-((E)-2-cyanovinyl)phenyl]-2-cyclopentylacetyl}amino)-4-fluorobenzyl]cyclopropanecarboxylate 

Relevant academic research and scientific papers

Discovery and optimization of pyridyl-cycloalkyl-carboxylic acids as inhibitors of microsomal prostaglandin E synthase-1 for the treatment of endometriosis

Here we report on novel and potent pyridyl-cycloalkyl-carboxylic acid inhibitors of microsomal prostaglandin E synthase-1 (PTGES). PTGES produces, as part of the prostaglandin pathway, prostaglandin E2 which is a well-known driver for pain and inflammatio

SUBSTITUTED PYRIDYL-CYCLOALKYL-CARBOXYLIC ACIDS, COMPOSITIONS CONTAINING THEM AND MEDICAL USES THEREOF

The present invention relates to substituted Pyridyl-cycloalkyl- carboxylic acids of general formula (I), to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular in mammals, such as diseases associated with pains, or for the treatment or prophylaxis of pain syndromes (acute and chronic), inflammatory-induced pain, pelvic pain, cancer-associated pain, endometriosis-associated pain as well as endometriosis and adenomyosis as such, cancer as such, and proliferative diseases as such like endometriosis.

Substituted 1-benzylcycloalkylcarboxylic acids and the use thereof

The present application relates to novel substituted 1-benzylcycloalkylcarboxylic acid derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular disorders.