31053-10-8

Basic information

• Product Name: 4-iodocyclohexan-1-one
• Synonyms: 4-iodocyclohexan-1-one
• CAS NO: 31053-10-8
• Molecular Weight: 224.041
• Mol File: 31053-10-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4-iodocyclohexan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-iodocyclohexan-1-one(31053-10-8)
• EPA Substance Registry System: 4-iodocyclohexan-1-one(31053-10-8)

Safety Data

• Hazardous Substances Data: 31053-10-8(Hazardous Substances Data)

Upstream product

• 4160-49-0 bicyclo[3.1.0]hexan-2-one 
• 21299-26-3 4-chlorocyclohexanone 
• 66980-41-4 3-(chloromethyl)cyclopentanone 
• 874-61-3 4-oxocyclohexanecarboxylic acid 
• 13482-22-9 4-hydroxycyclohexanone 
• 23511-04-8 4-oxocyclohexyl 4-methylbenzenesulfonate 
• 120790-24-1 1-iodo-5-hexen-2-one 

Downstream Products

• 6297-22-9 4-carbomethoxycyclohexanone 
• 58753-02-9 4-benzoylcyclohexanone 
• 4894-75-1 1-phenyl-4-cyclohexanone 
• 38580-68-6 4-hydroxymethyl-cyclohexanone 

Relevant articles and documents

Powerful solvent effect of water in radical reaction: Triethylborane-induced atom-transfer radical cyclization in water

Triethylborane-induced atom-transfer radical cyclization of iodo acetals and iodoacetates in water is described. Radical cyclization of iodo acetal proceeded smoothly both in aqueous methanol and in water. Atom-transfer radical cyclization of allyl iodoac

Photochemical Decarboxylative C(sp3)-X Coupling Facilitated by Weak Interaction of N-Heterocyclic Carbene

While N-hydroxyphthalimide (NHPI) ester has emerged as a powerful reagent as an alkyl radical source for a variety of C-C bond formations, the corresponding C(sp3)-N bond formation is still in its infancy. We demonstrate herein transition-metal-free decarboxylative C(sp3)-X bond formation enabled by the photochemical activity of the NHPI ester-NaI-NHC complex, giving primary C(sp3)-(N)phth, secondary C(sp3)-I, or tertiary C(sp3)-(meta C)phth coupling products. The primary C(sp3)-(N)phth coupling offers convenient access to primary amines.

Atom Transfer Cyclization Reactions of α-Iodo Esters, Ketones, and Malonates: Examples of Selective 5-Exo, 6-Endo, 6-Exo, and 7-Endo Ring Closures

The preparation and free-radical cyclization reactions of unsaturated α-iodo esters, ketones, and malonates have been investigated.For example, sunlamp irradiation of methyl 2-iodo-6-heptenoate in benzene in the presence of 10 mol percent hexabutylditin produces methyl 2-(iodomethyl)cyclopentanecarboxylate (cis and trans) and methyl 3-iodocyclohexanecarboxylate in a ratio of 93/7 in a combined yield of 86percent.The γ-iodo carbonyl products can either be isolated (in most cases) or converted in situ to deiodinated products (with Bu3SnH) or lactones (by heating).Five-, six-, or seven-membered rings selectively form, depending on chain length and alkene substitution.Terminal alkene substituents favor exo cyclization while internal alkene substituents promote endo cyclization.A preference for endo closure is also observed when there is a carbonyl group "inside" the forming ring.A detailed analysis of reaction rates indicates that these isomerizations proceed by an iodine atom transfer chain mechanism, and thus the observed selectivities are due to the kinetic substituent effects.The results contrast the thermodynamically controlled hydrogen atom transfer cyclizations of Julia.A new procedure for the removal of tin byproducts is described.