31088-57-0Relevant academic research and scientific papers
Efficient synthesis of 3-methylene-2-pyrrolidinone and highly exoselective diels-alder addition to cyclopentadiene
Fotiadu, Frederic,Pardigon, Olivier,Buono, Gerard,Le Corre, Maurice,Hercouet, Alain
, p. 867 - 870 (1999)
A new efficient synthesis of 3-methylene 2-pyrrolidinone 1 involving ylide-lactame 6 is reported. Diels-Alder cycloadditions of 1 to cyclopentadiene exhibited very high exoselectvities, regardless Of the experimental conditions. These results confirm the generality of exoselectivity for conformationally restricted s-cis dienophiles and indicate that the dienophile functionality and dipole moment have little influence on its magnitude.
Synthesis, Characterization, and Evaluation of Cytotoxicity of Poly(3-methylene-2-pyrrolidone)
Heyns, Ingrid M.,Pfukwa, Rueben,Klumperman, Bert
, p. 1795 - 1800 (2016)
The homo- and copolymerization of 3-methylene-2-pyrrolidone (3M2P) is introduced. 3M2P is readily polymerized via conventional free radical polymerization, and two reversible deactivation radical polymerization methods including reversible addition-fragmentation (chain) transfer and single-electron-transfer living radical polymerization. Poly(3M2P) has a high thermal stability and a very high glass transition temperature. Poly(3M2P) does not dissolve in most common organic solvents, but it has a high aqueous solubility. Cytotoxicity tests reveal that it is nontoxic to cells, even up to concentrations of 1 mg/mL. This adds poly(3M2P) to the family of water-soluble and biocompatible pyrrolidone-based vinyl polymers.
