310890-68-7

Upstream product

• 2018-61-3 (S)-2-acetylamino-3-phenylpropanoic acid 
• 310890-42-7 [4(S)-azido-3(S)-isobutyl-5(R)-(2-methoxy-ethoxy)-tetrahydro-furan-2(S)-ylmethoxy]-tert-butyl-diphenyl-silane 
• 310890-46-1 5(S)-(tert-butyl-diphenyl-silanyloxymethyl)-4(S)-isobutyl-2(R)-(2-methoxy-ethoxy)-tetrahydro-furan-3(S)-ylamine 
• 310890-56-3 2(S)-acetylamino-N-[5(S)-hydroxymethyl-4(S)-isobutyl-2(R)-(2-methoxy-ethoxy)-tetrahydro-furan-3(S)-yl]-3-phenyl-propionamide 
• 310890-50-7 2(S)-acetylamino-N-[5(S)-(tert-butyl-diphenyl-silanyloxymethyl)-4(S)-isobutyl-2(R)-(2-methoxy-ethoxy)-tetrahydro-furan-3(S)-yl]-3-phenyl-propionamide 

Relevant academic research and scientific papers

Tetrahydrofuran as a scaffold for peptidomimetics. Application to the design and synthesis of conformationally constrained metalloproteinase inhibitors

Enantiopure functionalized tetrahydrofurans were synthesized as prototypical conformationally constrained analogs of acyclic succinic acid-based inhibitors of metalloproteinases. While preliminary docking study showed good congruence with a potent inhibitor, the biological results were disappointing. Molecular dynamics simulation revealed the weakness of the H-bond interactions. (C) 2000 Elsevier Science Ltd.