310903-46-9

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 13277-99-1 4-methylbenzaldehyde-α-d₁ 
• 310903-47-0 (S)-p-trifluoromethylbenzyl-1-d alcohol 
• 104-87-0 4-methyl-benzaldehyde 

Relevant academic research and scientific papers

Preparation of optically active deuterated primary alcohols: Enantioselective borodeuteride reduction of aldehydes catalyzed by cobalt complexes

The enantioselective borodeuteride reduction of aldehydes catalyzed by optically active β-ketoiminato cobalt complexes afforded the corresponding chiral deuterated primary alcohols with a high degree of deuteration and good enantiomeric excess.

Asymmetric transfer hydrogenation of benzaldehydes

(Equation Presented) A combined system of RuCl[(R,R)-YCH(C6H5)CH(C6H5)NH 2](η6-arene) (Y = NSO2C6H4-4-CH3 or O) and t-C4H9OK catalyzes the asymmetric transfer hydrogenation of various benzaldehyde-1-d derivatives with 2-propanol to yield (R)-benzyl-1-d alcohols in 95-99% ee and with >99% isotopic purity. Reaction of benzaldehydes with a DCO2D-triethylamine mixture and the R,R catalyst affords the S deuterated alcohols in 97-99% ee.