31118-87-3 Usage
Uses
Used in Personal Care Products Industry:
1-(2,4,6-TRICHLOROPHENYL)-2-THIOUREA is used as an antimicrobial agent for its ability to inhibit bacterial and fungal growth in products such as soaps, detergents, and body washes, thereby enhancing their effectiveness in maintaining hygiene and preventing infections.
However, due to concerns regarding its environmental persistence and potential health impacts, including the disruption of hormone function and negative effects on aquatic life, there is an ongoing effort to regulate and reduce the use of 1-(2,4,6-TRICHLOROPHENYL)-2-THIOUREA in consumer products. This has led to increased research into alternative antimicrobial agents that are both effective and environmentally friendly.
Check Digit Verification of cas no
The CAS Registry Mumber 31118-87-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,1,1 and 8 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 31118-87:
(7*3)+(6*1)+(5*1)+(4*1)+(3*8)+(2*8)+(1*7)=83
83 % 10 = 3
So 31118-87-3 is a valid CAS Registry Number.
InChI:InChI=1/C7H5Cl3N2S/c8-3-1-4(9)6(5(10)2-3)12-7(11)13/h1-2H,(H3,11,12,13)
31118-87-3Relevant academic research and scientific papers
Discovery of aminothiazole derivatives as novel human enterovirus A71 capsid protein inhibitors
Cai, Yang,Chen, Yinuo,Dong, Chune,Lan, Ke,Lei, Ping,Tang, Qi,Wu, Shuwen,Xu, Ting,Xu, Zhichao,Zhou, Hai-Bing,Zou, Wenting
, (2022/03/15)
Enterovirus A71 (EV-A71), one of the major pathogens that causes hand, foot and mouth disease (HFMD), has seriously threatened the health and safety of young children. In this study, aminothiazole derivatives were synthesized and screened against EV-A71 in Rhabdomyosarcoma (RD) cells. The best compound (12s), with a biphenyl group, showed activity against EV-A71 (EC50: 0.27 μM) but also against a series of different human enteroviruses without significant cytotoxicity (CC50 > 56.2 μM). Mechanistic studies including time-of-drug-addition assays, viral entry assays and microscale thermophoresis (MST) experiments, showed that 12s binds to EV-A71 capsid and blocks the binding between the viral protein VP1 and the relevant human scavenger receptor class B member 2 (hSCARB2).
