31151-19-6

Basic information

• Product Name: 1H-Indole,2-methyl-3-(1-methylethyl)-(9CI)
• Synonyms: 1H-Indole,2-methyl-3-(1-methylethyl)-(9CI);3-Isopropyl-2-methyl-1H-indole
• CAS NO: 31151-19-6
• Molecular Formula: C₁₂H₁₅N
• Molecular Weight: 173.25
• Product Categories: ISOPROPYL
• Mol File: 31151-19-6.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 297.331°C at 760 mmHg
• Flash Point: 124.313°C
• Appearance: /
• Density: 1.03g/cm³
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.6
• CAS DataBase Reference: 1H-Indole,2-methyl-3-(1-methylethyl)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole,2-methyl-3-(1-methylethyl)-(9CI)(31151-19-6)
• EPA Substance Registry System: 1H-Indole,2-methyl-3-(1-methylethyl)-(9CI)(31151-19-6)

Safety Data

• Hazardous Substances Data: 31151-19-6(Hazardous Substances Data)

Usage

Chemical classification

Indole derivative

Structure

2-methyl-3-(1-methylethyl) indole moiety

Type of ring

Heterocyclic aromatic ring

Usage in

Organic synthesis and pharmaceutical research

Reactivity

Versatile

Biological activities

Potential activities

Application

Building block for synthesis of various organic compounds

Importance in

Medicinal chemistry and drug discovery

InChI:InChI=1/C12H15N/c1-8(2)12-9(3)13-11-7-5-4-6-10(11)12/h4-8,13H,1-3H3

Upstream product

• 21020-27-9 4-methylpent-2-yne 
• 615-43-0 2-iodophenylamine 
• 563-80-4 3-methyl-butan-2-one 
• 100-63-0 phenylhydrazine 
• 59-88-1 phenylhydrazine hydrochloride 
• 108-10-1 4-methyl-2-pentanone 
• 615-36-1 2-bromoaniline 
• 933039-47-5 1-methyl-1-(2-methyl-1H-3-indolyl)ethyl (4-methylphenyl)sulfone 
• 6228-39-3 1-(4-methylpentan-2-ylidene)-2-phenylhydrazine 
• 95-20-5 2-methyl-1H-indole 
• 67-64-1 acetone 
• 75-30-9 2-iodo-propane 

Relevant articles and documents

Synthesis of 3-(2-nitroalkyl) indoles by reaction of 3-(1-arylsulfonylalkyl) indoles with nitroalkanes

Sulfonyl indoles act as effective precursors of vinylogous imino derivatives in the reaction with nitroalkanes under basic conditions leading to the corresponding nitro indoles in good yield. This procedure represents an effective option to the classical

Palladium-Catalyzed Amination/Dearomatization Reaction of Indoles and Benzofurans

This report describes a palladium-catalyzed dearomatization and amination tandem reaction of 2,3-disubstituted indoles and benzofurans via the Catellani strategy. This reaction provides a new method for the construction of amino-substituted indoline-fused cyclic and benzofuran spiro compounds in good yields. The reaction has broad functional group compatibility and substrate scope.

Facile construction of pyrrolophenanthridone skeleton via a one-pot intramolecular Heck reaction and oxidation

Construction of pyrrolophenanthridone skeleton via a one-pot Pd-catalyzed intramolecular Heck reaction followed by oxidation has been achieved in moderate to good yields. The reaction mechanism has been proposed.