3116-07-2Relevant academic research and scientific papers
Synthesis of Ring-A and -B Substituted 17α-Acetoxypregnan-20-one Derivatives with Potential Activity on the Digitalis Receptor in Cardiac Muscle
Templeton, John F.,Kumar, V. P. Sashi,Kim, Ryungsoon S.,LaBella, Frank S.
, p. 1361 - 1368 (2007/10/02)
The synthesis of C-6 substituted (methyl, hydroxy, acetoxy, methoxy, ethoxy, methoxycarbonyloxy, ethoxycarbonyloxy, fluoro, chloro, bromo) 5α,5β,C-4 unsaturated and C-4,6 unsaturated derivatives of 17α-acetoxypregn-4-ene-3,20-dione (17α-acetoxyprogesterone) are reported.A convenient synthesis of 6α-hydroxy derivatives by selective reduction of the 4-ene-3,6-dione system is described as is the formation of 6α-alkoxycarbonyl derivatives.Synthesis of a 5α-hydroxy-6-ketone via 5β,6β-epoxide with N-bromosuccinimide is reported.A new preparation of 3α-hydroxy-5α-derivatives from the 4-en-3-one group has been carried out. (1)H n.m.r. are recorded.These compounds were synthesized to test for ouabain displacement activity an the digitalis receptor in cardiac muscle.
