311767-65-4

Usage

InChI:InChI=1/C7H4ClNO2/c8-5-1-6(3-10)9-7(2-5)4-11/h1-4H

Upstream product

• 1817-20-5 4-chloro-2,6-bis(hydroxymethyl)pyridine 
• 19872-91-4 dimethyl 4-hydroxypyridine-2,6-dicarboxylate 
• 499-51-4 Chelidamic acid 
• 5371-70-0 dimethyl 4-chloro-2,6-pyridinedicarboxylate 
• 1422463-80-6 4-chloro-2,6-bis(1-pyrrolidinylcarbonyl)pyridine 
• 71022-75-8 4-chloropyridine-2,6-dicarbonyl dichloride 

Relevant academic research and scientific papers

Functionalized 4,4′-Bipyridines: Synthesis and 2D Organization on Highly Oriented Pyrolytic Graphite

Commercial 4,4′-bipyridine is a popular scaffold that is primarily employed as a linker in 3D self-assembled architectures such as metallo-organic frameworks or as a connector in 2D networks. The introduction of alkyl substituents on the bipyridine skelet

A formal anti-Markovnikov hydroalkoxylation of allylic alcohols with a ruthenium catalyst

Hydroalkoxylation of C-C double bonds was achieved through the use of a ruthenium catalyst. The reaction of allylic alcohols with nucleophilic alcohols was carried out in the presence of a ruthenium catalyst prepared by RuClH(CO)(PPh3)3 and 2,6-bis(n-butyliminomethyl)-4-(piperidin-1-yl)pyridine under mild reaction conditions to afford the corresponding γ-alkoxypropanols in good yield.

A convenient approach for the synthesis of 2,6-diformyl- and 2,6-diacetylpyridines

2,6-Diformyl- and 2,6-diacetylpyridines are readily accessed in good yields (60-90%) via the single-pot reaction of 2,6-pyridine dicarboxamides with LiAlH4 or MeMgCl in THF at 0-20°C. The high efficiency of the method illustrates the significance of solubility in the reduction and alkylation of difunctionalized substrates.

Oxidation-resistant indicator macromolecule

In one aspect, the present invention relates to an implantable device for detecting the presence or concentration of an analyte in an aqueous environment in vivo. The device includes a macromolecule that comprises a copolymer of: a) one or more indicator component monomers which individually are not sufficiently water soluble to permit their use in an aqueous environment for detecting the presence or concentration of said analyte; b) one or more hydrophilic monomers; and c) one or more catalytic antioxidant monomers; such that the macromolecule is capable of detecting the presence or concentration of the analyte in an aqueous environment. The presence of the catalytic antioxidant reduces or prevents oxidative damage to the macromolecule.