311787-96-9

Basic information

• Product Name: 2-[(4-FLUOROBENZYL)SULFANYL]-3-PHENYL-4(3H)-QUINAZOLINONE
• Synonyms: 2-[(4-FLUOROBENZYL)SULFANYL]-3-PHENYL-4(3H)-QUINAZOLINONE;2-{[(4-fluorophenyl)methyl]sulfanyl}-3-phenyl-3,4-dihydroquinazolin-4-one
• CAS NO: 311787-96-9
• Molecular Formula: C₂₁H₁₅FN₂OS
• Molecular Weight: 362.42
• Mol File: 311787-96-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-[(4-FLUOROBENZYL)SULFANYL]-3-PHENYL-4(3H)-QUINAZOLINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(4-FLUOROBENZYL)SULFANYL]-3-PHENYL-4(3H)-QUINAZOLINONE(311787-96-9)
• EPA Substance Registry System: 2-[(4-FLUOROBENZYL)SULFANYL]-3-PHENYL-4(3H)-QUINAZOLINONE(311787-96-9)

Safety Data

• Hazardous Substances Data: 311787-96-9(Hazardous Substances Data)

Usage

Structure

Quinazolinone derivative with a fluorobenzyl sulfanyl group and a phenyl group attached to the quinazolinone ring

Potential pharmacological activities

Studied for its potential therapeutic properties in the field of medicinal chemistry

Further research needed

Requires additional research to fully understand its biological and pharmacological effects.

Upstream product

• 13037-60-0 1-bromo-2-isothiocyanatobenzene 
• 103-71-9 phenyl isocyanate 
• 459-46-1 4-Fluorobenzyl bromide 
• 118-92-3 anthranilic acid 
• 103-72-0 phenyl isothiocyanate 
• 18741-24-7 3-phenyl-2-thioxo-2,3-dihydro-1H-quinazolin-4-one 

Relevant articles and documents

Integrated one-flow synthesis of heterocyclic thioquinazolinones through serial microreactions with two organolithium intermediates

The synthesis of pharmaceutical compounds via short-lived intermediates in a microreactor is attractive, because of the fast flow and high throughput. Additionally, intermediates can be utilized sequentially to efficiently build up a library in a short time. Here we present an integrated microfluidic synthesis of biologically active thioquinazolinone libraries. Generation of o-lithiophenyl isothiocyanate and subsequent reaction with aryl isocyanate is optimized by controlling the residence time in the microreactor to 16 ms at room temperature. Various S-benzylic thioquinazolinone derivatives are synthesized within 10 s in high yields (75-98%) at room temperature. These three-step reactions involve two organolithium intermediates, an isothiocyanate-functionalized aryllithium intermediate, and a subsequent lithium thiolate intermediate. We also demonstrate the gram-scale synthesis of a multifunctionalized thioquinazolinone in the microfluidic device with a high yield (91%) and productivity (1.25 g in 5 min).