311804-41-8Relevant academic research and scientific papers
A novel and efficient approach to highly substituted indolizines via 5-endo-trig iodocyclization
Kim, Ikyon,Won, Hye Kyoung,Choi, Jihyun,Lee, Ge Hyeong
, p. 12954 - 12960 (2008/03/17)
A new approach to indolizines has been developed using a 5-endo-trig iodocyclization of allylic esters followed by isomerization and dehydroiodination facilitated by triethylamine at rt. This mild procedure enabled us to synthesize a number of highly subs
2-(2-piperidyl)- and 2-(2-pyrrolidyl)chromans as nicotine agonists: Synthesis and preliminary pharmacological characterization
Efange,Tu,Von Hohenberg,Francesconi,Howell,Rampersad,Todaro,Papke,Kung
, p. 4704 - 4715 (2007/10/03)
As part of an effort to develop a new class of subtype selective nicotine agonists, we have synthesized and tested a group of 12 hydroxylated 2-(2-piperidyl)- and 2-(2-pyrrolidyl)chromans. In rat brain membranes, all 12 compounds displayed poor affinity f
