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Usage

Uses

Used in Pharmaceutical Industry:
2-AMINO-2-(4-FLUORO-PHENYL)-PROPIONIC ACID is used as a synthetic intermediate for the development of new pharmaceuticals, leveraging its structural features to enhance the properties of target drugs.
Used in Agrochemical Industry:
In the agrochemical sector, 2-AMINO-2-(4-FLUORO-PHENYL)-PROPIONIC ACID is utilized as a key component in the synthesis of agrochemicals, potentially improving the effectiveness of pesticides and other agricultural chemicals.
Used in Medicinal Chemistry:
2-AMINO-2-(4-FLUORO-PHENYL)-PROPIONIC ACID serves as a valuable building block in medicinal chemistry, where its incorporation into drug molecules can lead to the discovery of novel therapeutic agents.
Used in Drug Discovery:
2-AMINO-2-(4-FLUORO-PHENYL)-PROPIONIC ACID is employed in drug discovery processes, where its unique structural elements may contribute to the identification of new lead compounds with potential therapeutic applications.
Used as a Research Tool in Biochemical Studies:
2-AMINO-2-(4-FLUORO-PHENYL)-PROPIONIC ACID is used as a research tool in biochemical studies to explore its biological activity and understand its interactions with biological systems, which can provide insights into its potential applications in medicine and pharmacology.

Upstream product

• 428-22-8 5-(4-fluoro-phenyl)-5-methyl-imidazolidine-2,4-dione 
• 403-42-9 1-(4-fluorophenyl)ethanone 

Relevant academic research and scientific papers

New enzymatic methods for the synthesis of primary α-aminonitriles and unnatural α-amino acids by oxidative cyanation of primary amines with d-amino acid oxidase from porcine kidney

Oxidation of amino groups in amines or amino acids activates the sp3 Cα-H bond to form imines, making the alpha carbon atom a preferable target for nucleophilic reagents such as cyanide. Therefore, we focused on the oxidase reaction for the production of primary α-aminonitriles via imines. d-Amino acid oxidase from porcine kidney (pkDAO) and l-amino acid oxidase from Crotalus atrox catalyzed the synthesis of 2-amino-2-cyano-3-phenylpropanoic acid from phenylalanine and potassium cyanide (KCN). Mutant pkDAO (Y228L/R283G) catalyzed the synthesis of racemic-2-methyl-2-phenylglycinonitrile from (R)-α-methylbenzylamine and KCN. Based on these results, we developed a new cascade reaction for the synthesis of unnatural α-amino acids from primary amines using mutant pkDAO and nitrilase AY487533. This is the first report of the enzymatic synthesis of primary α-aminonitriles and unnatural α-amino acids. These methods will contribute widely to the synthesis of primary α-aminonitriles and unnatural α-amino acids in aqueous systems.

Water soluble phosphines: Part XIII. Chiral phosphine ligands with amino acid moieties

Nucleophilic phosphination of the potassium or sodium salt of the fluorophenylalanines (1a, 2a) or -glycines (3a, 4a) with potassium phosphides Ph(R)PK (R=Me, Ph) yields chiral phosphine ligands (1-7) with amino acid moieties. The X-ray structure of 3·2H2O (space group Pbca) has been determined showing a betaine type structure for the amino acid moiety. The α-methyl derivatives of the phosphinophenylglycines (10, 11) were obtained in an analogous manner as 1-7. ortho- and para-Fluoroacetophenones have been employed as starting material for the syntheses of α-[4-fluorophenyl]-α-methylglycine (9c) and its ortho-isomer (8c), the X-ray structure of its monohydrate has been determined (space group P1?). The N-acetyl (3b, 8e) and ester derivatives (3d, 8d) of 3 and 8c are accessible using standard procedures. Resolution of the diastereomeric salt 12 obtained from (S)-(+)-2-hydroxymethylpyrrolidine and racem-8e by fractionated crystallization yielded the (S,R)-isomer. The absolute configuration of (S,R)-12 was determined by X-ray structural analysis (space group P212121). Cleavage of (S,R)-12 with hydrochloric acid gave enantiopure (R)-8e [α]D20=-30.9° (c=1, CH3OH).