312-95-8

Usage

Uses

Used in Pharmaceutical Industry:
alpha,alpha,alpha,alpha',alpha'-pentafluoro-o-xylene is used as a building block in the synthesis of various pharmaceuticals. Its unique properties, including high thermal and chemical stability, make it a valuable component in the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical sector, alpha,alpha,alpha,alpha',alpha'-pentafluoro-o-xylene is utilized as a key intermediate in the production of fluorinated agrochemicals. Its stability and reactivity contribute to the effectiveness and performance of these compounds in agricultural applications.
Used in Advanced Materials Industry:
alpha,alpha,alpha,alpha',alpha'-pentafluoro-o-xylene is employed in the synthesis of advanced materials, such as high-performance polymers and coatings. Its exceptional stability and fluorine content make it suitable for applications requiring durability and resistance to harsh conditions.
It is crucial to handle alpha,alpha,alpha,alpha',alpha'-pentafluoro-o-xylene with care due to its hazardous nature, which may pose risks to human health and the environment if not managed properly.

Upstream product

• 2741-57-3 o-dichloromethyltrichloromethylbenzene 
• 433-95-4 1,2-bis(trifluoromethyl)benzene 
• 95-47-6 o-xylene 
• 1577232-80-4 2,2-difluoro-1-phenyl-2-(2-(trifluoromethyl)phenyl)ethanone 
• 395-01-7 2,2-difluoro-1-phenylethanone 
• 392-83-6 o-trifluoromethylphenyl bromide 

Downstream Products

• 447-61-0 2-Trifluoromethylbenzaldehyde 
• 312-94-7 2-trifluoromethylbenzoyl chloride 
• 312-91-4 1-(chloro-difluoro-methyl)-2-trifluoromethyl-benzene 

Relevant academic research and scientific papers

Selective Late-Stage Hydrodefluorination of Trifluoromethylarenes: A Facile Access to Difluoromethylarenes

A selective reductive monodefluorination reaction of trifluoromethyl arenes was developed. Mediated by magnesium metal, various difluoromethylated aromatics were accessed at room temperature in the presence of acetic acid. This protocol shows tolerance to a wide range of functional groups and it was applicable in late-stage hydrodefluorination of complex pharmaceutical compounds, affording the corresponding CF2H analogues and their deuterated (CF2D) counterparts.

A O-trifluoro methyl process for the preparation of formaldehyde

The invention discloses a method for preparing o-trifluoromethyl benzaldehyde. The method for preparing the o-trifluoromethyl benzaldehyde, disclosed by the invention, comprises the following steps: in the presence of a catalyst, carrying out hydrolysis reaction on a mixture of o-trifluoromethyl methylbenzene bichloride, o-trifluoromethyl chloro-fluoro-methylbenzene and o-trifluoromethyl methylbenzene difluoride and water at the temperature of 80-150 DEG C to obtain, wherein the mass of the catalyst accounts for 0.01-10% of the mass of the mixture. The method disclosed by the invention is cheap and easily available in raw materials, low in cost, little in wastewater, low in energy consumption and simple in operation and can be suitable for industrial production. The structural formula of the o-trifluoromethyl benzaldehyde is shown in the specification.

Pd-catalyzed α-arylation of α,α-difluoroketones with aryl bromides and chlorides. A route to difluoromethylarenes

We report the Pd-catalyzed α-arylation of α,α- difluoroketones with aryl and heteroaryl bromides and chlorides catalyzed by an air- and moisture-stable palladacyclic complex containing P(t-Bu)Cy2 as ligand. The combination of this Pd-catalyzed arylation and base-induced cleavage of the acyl-aryl C-C bond within the α-aryl-α,α- difluoroketone constitutes a one-pot, two-step procedure to synthesize difluoromethylarenes from aryl halides. A broad range of electronically varied aryl and heteroaryl bromides and chlorides underwent these two transformations, providing α-aryl-α,α-difluoroketones, difluoromethylarenes, and difluoromethylheteroarenes in high yields.

METAL-CATALYZED COUPLING OF ARYL AND VINYL HALIDES WITH ALPHA, ALPHA-DIFLUOROCARBONYL COMPOUNDS

The coupling of aryl, heteroaryl, and vinyl halides with α,α-difluoroketones or silyl ethers or siylenol ethers of α,α-difluoroketones and α,α-difluoroamides and esters are described. Further derivatization of the coupling products (such as ketone cleavage and Baeyer-Villiger oxidation) is also described.