31209-24-2Relevant academic research and scientific papers
Carcinostatic activity of a thiazolidinonylidene hydrazonothiazolidinone derivative against DMBA induced mammary carcinomata in female Sprague Dawley rats
Schmidt-Ruppin,Meisels,Schott,Storni,Schieweck
, p. 823 - 825 (1973)
5 methyl 3 (2 methylallyl) 2 (3 methyl 4 oxo 2 thiazolidinyldene) hydrazono 4 thiazolidinone was found to have a wide therapeutic spectrum and to have marked carcinostatic properties in DMBA induced mammary carcinomata of female Sprague Dawley rats. A lesser chemotherapeutic effect was also found in growth of Walker CaSa 256, DMBA induced skin cancer and Ehrlich ascites carcinoma.
Use of carbazones as novel active ingredients in medicaments
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, (2008/06/13)
Compounds of formula I STR1 wherein X and Y are each independently of the other thio or sulfynyl, R1 is lower alk-2-en-1-yl, lower alk-3-en-2-yl, lower alk-2--yn-1-yl, or lower alkyl that is substituted in the 2,3-position by radicals that can be eliminated to form a double bond, R2 is hydrogen and R3 is unsubstituted methyl or methyl substituted by a radical that can be eliminated together with hydrogen Rhd 2 to form a double bond, or R2 and R3 are each hydrogen or lower alkyl or together are methylene, R4 is free or protected hydroxy, or hydrogen, and R5 is hydrogen, lower alkyl, lower alk-2-en-1-yl, lower alk-2-yn-1-yl, or lower alkyl that is substituted in the 2,3-position by radicals that can be eliminated to form a double bond, and their pharmaceutically acceptable salts may be used in a novel manner for the treatment of disorders of the rheumatoid type.
