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Pyrimidine, 4-chloro-2-(methoxymethyl)-6-methyl-, is a chemical compound belonging to the pyrimidine family, characterized by a six-membered heterocyclic ring containing four carbon atoms and two nitrogen atoms. This specific compound features a 4-chloro substituent, a 2-methoxymethyl group, and a 6-methyl group. It is an important intermediate in the synthesis of various pharmaceuticals and agrochemicals, particularly those with antiviral and anticancer properties. The compound's unique structure and functional groups make it a valuable building block in the development of new therapeutic agents.

3122-80-3

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3122-80-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 3122-80-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,1,2 and 2 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 3122-80:
(6*3)+(5*1)+(4*2)+(3*2)+(2*8)+(1*0)=53
53 % 10 = 3
So 3122-80-3 is a valid CAS Registry Number.

3122-80-3Relevant academic research and scientific papers

TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS OF USE

-

, (2018/03/25)

Described herein are tricyclic compounds with phosphoinositide-3 kinase (PI3K) modulation activity or function having the Formula I structure: or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such PI3K modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon PI3K dysregulation.

Studies on Pyrimidine Derivatives. XXXII. Reaction of 4-Substituted 2,6-Dimethylpyrimidine 1-Oxides with Phosphoryl Chloride

Sakamoto, Takao,Yoshizawa, Hiroshi,Kaneda, Sohichi,Hama, Yoshiaki,Yamanaka, Hiroshi

, p. 4533 - 4538 (2007/10/02)

The reaction of 2,6-dimethyl-4-phenylpyrimidine 1-oxide with phosphoryl chloride gave 4-chloromethyl-2-methyl-6-phenylpyrimidine exclusively.In contrast, 2,6-dimethyl-4-methoxy-pyrimidine 1-oxide and 2,6-dimethyl-4-dimethylaminopyrimidine 1-oxide reacted with the same reagent to give the corresponding 2-chloromethylpyrimidines predominantly.Keywords - pyrimidine N-oxide; chloromethylpyrimidine; phosphoryl chloride; siteselective reaction; substituent effect

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